Mice performance on the staircase test following acute ethanol administration

Ronit Weizman*, Lior Paz, Yakov Peter, Chaim G. Pick

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This study examined the effect of acute ethanol administration as compared to diazepam on the number of rearing events and the number of steps ascended in the mouse staircase test, an animal model sensitive to benzodiazepines. Acute ethanol administration, similar to acute diazepam administration, reduces rearing (at doses that do not reduce climbing) in the staircase test. This effect of acute ethanol administration is insensitive to the benzodiazepine antagonist flumazenil and is not consistently counteracted by the partial inverse agonist Ro15-4513. It seems that the mouse staircase test is an efficient paradigm for studying agents active at the gamma-aminobutyric acid (GABA∧) receptor complex, including ethanol.

Original languageEnglish
Pages (from-to)491-495
Number of pages5
JournalPharmacology Biochemistry and Behavior
Volume68
Issue number3
DOIs
StatePublished - 2001

Keywords

  • Benzodiazepine
  • Diazepam
  • Ethanol
  • Flumazenil
  • Gamma-aminobutyric acid (GABA) receptor
  • Staircase test

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