Metoclopramide for nausea and vomiting of pregnancy: A prospective multicenter international study

Matitiahu Berkovitch, Paul Mazzota, Revital Greenberg, Daniel Elbirt, Antony Addis, Lavinia Schuler-Faccini, Paul Merlob, Judy Arnon, Bracha Stahl, Laura Magee, Myla Moretti, Asher Ornoy

Research output: Contribution to journalArticlepeer-review


Nausea and vomiting are very common during pregnancy, mainly throughout the first trimester. Metoclopramide is a dopamine receptor blocking drug that is commonly used to treat nausea and vomiting. The aim of this prospective study was to investigate the effect on the fetus of intrauterine exposure to metoclopramide. One hundred and seventy-five women who received metoclopramide and consulted 6 teratogen information centers in Israel, Italy, Brazil, and Canada were studied. Women exposed to metoclopramide were paired for age, smoking and alcohol consumption habits with women exposed to nonteratogens. Women in the metoclopramide group had a significantly higher rate of premature births (8.1%) as compared with the control group (2.4%) (p = 0.02, relative risk = 3.37, 95% confidence interval 1.12-10.12). Rates of major malformations in the metoclopramide group (4.4%) did not differ from controls (4.8%) (p = 0.84, relative risk = 0.91, 95% confidence interval 0.34-2.45). According to our findings, metoclopramide use during the first trimester of pregnancy does not appear to be associated with an increased risk of malformations, spontaneous abortions, or decreased birth weight, however, larger studies are needed to confirm these observations.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalAmerican Journal of Perinatology
Issue number6
StatePublished - Aug 2002
Externally publishedYes


  • Metoclopramide
  • Nausea
  • Pregnancy
  • Vomiting


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