Methotrexate treatment of rheumatoid arthritis: Is a fortnightly maintenance schedule enough?

Moshe Tishler, Dan Caspi, Michael Yaron

Research output: Contribution to journalArticlepeer-review

Abstract

In 15 patients with rheumatoid arthritis who were in clinical remission the weekly regimen of methotrexate treatment was changed to fortnightly without a change in dose. A total of 13 patients completed a 12 month trial. No change in clinical or laboratory parameters occurred. There was no change in the use of analgesics or non-steroidal anti-inflammatory drugs and the patients remained in remission. Two patients had to be withdrawn after two and four months respectively because of a flare in disease activity. It is suggested that in most patients with rheumatoid arthritis who are treated with methotrexate and whose disease activity is stable a fortnightly regimen can be permitted without affecting drug efficacy.

Original languageEnglish
Pages (from-to)1330-1331
Number of pages2
JournalAnnals of the Rheumatic Diseases
Volume51
Issue number12
DOIs
StatePublished - 1992

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