Methotrexate therapy of tubal pregnancy

M. Goldenberg*, D. Bider, D. Admon, S. Mashiach, G. Oelsner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


Reports of successful treatment of ectopic pregnancies by administration of methotrexate have recently attracted a great deal of attention. This review summarizes the results of therapy with methotrexate in tubal pregnancy. Different technical approaches and pharmacological doses have been reported. These methods, however, present various problems, including the occurrence of toxicity, long therapeutic periods and treatment failure. With proper selection of patients, a success rate of ∼ 90% has been achieved. Preliminary assessment of subsequent fertility provides promising results. However, the majority of the reports do not include controls.

Original languageEnglish
Pages (from-to)660-666
Number of pages7
JournalHuman Reproduction
Issue number5
StatePublished - May 1993


  • Methotrexate
  • Tubal pregnancy


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