TY - JOUR
T1 - Methionine synthase A2756G and methylenetetrahydrofolate reductase A1298C polymorphisms are not risk factors for idiopathic venous thromboembolism
AU - Salomon, O.
AU - Rosenberg, N.
AU - Zivelin, A.
AU - Steinberg, D. M.
AU - Kornbrot, N.
AU - Dardik, R.
AU - Inbal, A.
AU - Seligsohn, U.
PY - 2001
Y1 - 2001
N2 - Hyperhomocysteinemia is a defined risk factor for venous thromboembolism (VTE). Several polymorphisms of genes encoding for enzymes acting in the remethylation pathway of homocysteine metabolism, ie, methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C, can cause increased homocysteine levels particularly in patients with deficiencies of folic acid, vitamin B6, or B12 and hence be potential risk factors for VTE. Indeed, homozygous MTHFR C677T was shown to be a mild risk factor for VTE by some, but not by all, investigators. In this study, we assessed the risk exerted by MS A2756G and MTHFR A1298C in a cohort of patients with idiopathic venous thromboembolism. Homozygosities for MS A2756G and MTHFR A1298C were not found to be statistically significant risk factors for VTE. In addition, no interactions were observed among MS A2756G, MTHFR A1298C and MTHFR C677T in conferring a risk of VTE.
AB - Hyperhomocysteinemia is a defined risk factor for venous thromboembolism (VTE). Several polymorphisms of genes encoding for enzymes acting in the remethylation pathway of homocysteine metabolism, ie, methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C, can cause increased homocysteine levels particularly in patients with deficiencies of folic acid, vitamin B6, or B12 and hence be potential risk factors for VTE. Indeed, homozygous MTHFR C677T was shown to be a mild risk factor for VTE by some, but not by all, investigators. In this study, we assessed the risk exerted by MS A2756G and MTHFR A1298C in a cohort of patients with idiopathic venous thromboembolism. Homozygosities for MS A2756G and MTHFR A1298C were not found to be statistically significant risk factors for VTE. In addition, no interactions were observed among MS A2756G, MTHFR A1298C and MTHFR C677T in conferring a risk of VTE.
KW - MS
KW - MTHFR
KW - Venous thromboembolism
UR - http://www.scopus.com/inward/record.url?scp=0035072876&partnerID=8YFLogxK
U2 - 10.1038/sj.thj.6200078
DO - 10.1038/sj.thj.6200078
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 11920232
AN - SCOPUS:0035072876
SN - 1466-4860
VL - 2
SP - 38
EP - 41
JO - Hematology Journal
JF - Hematology Journal
IS - 1
ER -