Methionine: A key regulatory compound in bacteria

Dvora Biran, Eliora Z. Ron*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In bacteria methionine is a key compound that regulates the synthesis of macromolecules and growth. The enzymes of methionine biosynthesis have a critical role in the adaptation to elevated temperatures and control the growth rate under these conditions. The genes coding for the biosynthetic methionine enzymes are under complex regulation which allows a quick response to changing physiological and environmental conditions. This chapter will discuss the physiological significance of methionine, the regulation of its synthesis and the evolution of methionine biosynthetic pathways. It will stress the fact that there are multiple enzymes for each step of the synthesis as well as a multitude of regulatory elements. This complexity probably reflects the importance of methionine in cellular metabolism and the necessity to monitor its cellular concentration with high sensitivity and precision.

Original languageEnglish
Title of host publicationMethionine
Subtitle of host publicationBiosynthesis, Chemical Structure and Toxicity
PublisherNova Science Publishers, Inc.
Number of pages7
ISBN (Print)9781626182462
StatePublished - Apr 2013


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