Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome

Giuseppe Morgante; Claudia Tosti; Raoul Orvieto; Maria C. Musacchio; Paola Piomboni; Vincenzo De Leo

doi:10.1016/j.fertnstert.2010.12.009

Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome

Giuseppe Morgante^*, Claudia Tosti, Raoul Orvieto, Maria C. Musacchio, Paola Piomboni, Vincenzo De Leo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months. The use of metformin was associated with a statistically significant reduction in insulin resistance and sex hormone-binding globulin levels, a statistically significant increase in serum androgen levels, and a consequent improvement in semen characteristics.

Original language	English
Pages (from-to)	2150-2152
Number of pages	3
Journal	Fertility and Sterility
Volume	95
Issue number	6
DOIs	https://doi.org/10.1016/j.fertnstert.2010.12.009
State	Published - May 2011
Externally published	Yes

Keywords

Metabolic syndrome
OTA
metformin
semen
testosterone

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10.1016/j.fertnstert.2010.12.009

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abstract = "To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months. The use of metformin was associated with a statistically significant reduction in insulin resistance and sex hormone-binding globulin levels, a statistically significant increase in serum androgen levels, and a consequent improvement in semen characteristics.",

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AU - Musacchio, Maria C.

AU - Piomboni, Paola

AU - De Leo, Vincenzo

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AB - To examine the appropriate treatment of oligo-terato-asthenozoospermic patients with metabolic syndrome, 45 patients were treated with metformin for 6 months. The use of metformin was associated with a statistically significant reduction in insulin resistance and sex hormone-binding globulin levels, a statistically significant increase in serum androgen levels, and a consequent improvement in semen characteristics.

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KW - OTA

KW - metformin

KW - semen

KW - testosterone

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Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndrome

Abstract

Keywords

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