TY - JOUR
T1 - Metastasizing placental site trophoblastic tumor
T2 - Immunohistochemical and DNA analysis. 2 case reports and a review of the literature
AU - Remadi, S.
AU - Lifschitz-Mercer, B.
AU - Ben-Hur, H.
AU - Dgani, R.
AU - Czernobilsky, B.
PY - 1997
Y1 - 1997
N2 - Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.
AB - Placental-site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia. The clinical behaviour of PSTT is usually benign, but sometimes it can be highly malignant with late recurrence and metastasis. We describe two cases of PSTT with pulmonary metastasis in patients aged 35 and 29 years respectively. The mitotic rate was elevated to 9 and 13 mitotic figures per 10 high-power fields respectively. Immunohistochemical staining showed a predominance of human placental lactogen (hPL) positive cells when compared with human chorionic gonadotropin (hCG) reactive cells in one case, and a reverse pattern in the other one. DNA measurement in one case showed an aneuploid tumor with a tetraploid DNA peak. The clinical behaviour of PSTT remains unpredictable, and there are no reliable means of predicting clinical outcome.
KW - Metastasis
KW - Placental site trophoblastic tumor
UR - http://www.scopus.com/inward/record.url?scp=0031046398&partnerID=8YFLogxK
U2 - 10.1007/BF02505316
DO - 10.1007/BF02505316
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AN - SCOPUS:0031046398
SN - 0932-0067
VL - 259
SP - 97
EP - 103
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 2
ER -
