Metastasis-related cell functions in primary and metastatic tumor cells of AKR lymphoma

O. Klein, N. Savion, A. Staroselsky, N. Donin, M. Huszar, Y. Wollman, J. Leibovici*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The metastatic phenotype is of extreme complexity. To complete all the stages of metastasis, the tumor cell must possess a whole series of functional abilities. Multiple biological markers are therefore needed to achieve a deeper understanding of the metastatic phenotype. In the present study we compared primary (PT) to metastatic tumor (MT) cells of two AKR lymphoma variants with respect to several cellular functions relevant to various steps of tumor dissemination. The MT cells of the TAU-44 variant had a higher capacity than the PT cells to attach to endothelial monolayers and ECM, exhibited a more elevated motility and a higher capacity to grow in the spleen as a metastatic target organ. However, the TAU-44-MT cells had a lower ability to grow in the kidney than the PT cells. The TAU-33-MT cells had a higher ability to attach to endothelial cells and to grow in both spleen and kidney but were less motile compared to PT cells. Metastatic cells showed, on the whole, higher ability to perform in most, but not all, stage-specific models than primary tumor cells.

Original languageEnglish
Pages (from-to)219-225
Number of pages7
JournalCancer Letters
Issue number2
StatePublished - 29 Mar 1996


  • AKR lymphoma
  • Metastatic phenotype
  • Tumor progression model


Dive into the research topics of 'Metastasis-related cell functions in primary and metastatic tumor cells of AKR lymphoma'. Together they form a unique fingerprint.

Cite this