Metamizol (dipyrone, optalgin) in pregnancy, is it safe? A prospective comparative study

Benjamin Bar-Oz, Maurizio Clementi, Elena Di Giantonio, Revital Greenberg, Monic Beer, Paul Merlob, Judy Arnon, Asher Ornoy, Deena M. Zimmerman, Matitiahu Berkovitch*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Aim: To assess the teratogenic effect of metamizol when used during the first trimester of pregnancy. Methods: One hundred and eight women who used metamizol during the first trimester of pregnancy were recruited from 4 teratogen information centers in Israel (3) and in Italy (1). The study group was paired for age, smoking habits and alcohol consumption with a comparative group exposed to acetaminophen. Results: Maternal demographics and history, birth weight, gestational age at delivery, rate of live births, spontaneous abortions and fetal distress were comparable in both groups. The rate of major malformations in the metamizol group (3%) did not differ significantly from the rate in the comparative group (2%) (P = 0.57, relative risk = 1.55, 95% confidence interval 0.26-9.05). Conclusions: Our data may suggest that exposure to metamizol during the first trimester of pregnancy is probably not associated with a significantly increased risk for malformations or spontaneous abortions.

Original languageEnglish
Pages (from-to)176-179
Number of pages4
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Issue number2
StatePublished - 1 Apr 2005


  • Congenital malformations
  • Metamizol
  • Pregnancy
  • Teratogenic effect


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