Metals in Dental Implants as a Trigger of Autoimmunity

Arad Dotan, Yehuda Shoenfeld

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    The immune system is a highly complex network of biological processes that have the ability to respond toward foreign stimuli, including bacteria, viruses, parasites, fungi, as well as toxins, and other unfamiliar exogenous materials. Numerous factors are involved in the stimulation of the innate and acquired immune responses, while some may contribute to hyperstimulation; those factors are commonly classified into three primary groups: genetic, epigenetic; environmental; and hormonal. There had been many claims over the year that metal materials are related to autoimmunity as environmental factors. A large proportion of contemporary dental crowns are composed of porcelain and seminoble and nonnoble metals, such as aluminum, chrome, and cobalt. However, these metal components are significantly associated with immune manifestations, leading some patients to implant rejection and side effects. We believe that long-term exposure to such metals can lead to ASIA syndrome, a combination of unspecific symptoms resembling fibromyalgia and chronic fatigue syndrome.

    Original languageEnglish
    Title of host publicationAutoimmune Disorders
    Subtitle of host publicationAdjuvants and Other Risk Factors in Pathogenesis
    Publisherwiley
    Pages337-340
    Number of pages4
    ISBN (Electronic)9781119858430
    ISBN (Print)9781119858416
    DOIs
    StatePublished - 1 Jan 2024

    Keywords

    • ASIA syndrome
    • autoimmunity
    • dental crowns
    • hyperstimulation
    • metal toxicity

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