Metal ion transporters and homeostasis

Research output: Contribution to journalReview articlepeer-review

Abstract

Transition metals are essential for many metabolic processes and their homeostasis is crucial for life. Aberrations in the cellular metal ion concentrations may lead to cell death and severe diseases. Metal ion transporters play a major role in maintaining the correct concentrations of the various metal ions in the different cellular compartments. Recent studies of yeast mutants revealed keg elements in metal ion homeostasis, including novel transport systems. Several of the proteins discovered in yeast are highly conserved, and defects in some of the yeast mutants could be complemented by their human homologs. The studies of yeast metal ion transporters helped to unravel the molecular mechanism of macrophage defense against bacterial infection and hereditary diseases.

Original languageEnglish
Pages (from-to)4361-4371
Number of pages11
JournalEMBO Journal
Volume18
Issue number16
DOIs
StatePublished - 16 Aug 1999

Keywords

  • Copper
  • Human diseases
  • Iron
  • Manganese
  • Metal ions
  • Transport
  • Yeast

Fingerprint

Dive into the research topics of 'Metal ion transporters and homeostasis'. Together they form a unique fingerprint.

Cite this