Metal-Helix Frameworks from Short Hybrid Peptide Foldamers

Rajkumar Misra, Abhijith Saseendran, Sanjit Dey, Hosahudya N. Gopi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The potential of structured peptides has not been explored much in the design of metal-organic frameworks (MOFs). This is partly due to the difficulties in obtaining stable secondary structures from the short α-peptide sequences. Here we report the design, crystal conformations, coordination site dependent different silver coordinated frameworks of short α,γ-hybrid peptide 12-helices consisting of terminal pyridyl moieties and the utility of metal-helix frameworks in the adsorption of CO 2 . Upon silver ion coordination the 12-helix terminated by the 3-pyridyl derivatives adopted a 2:2 macrocyclic structure, while the 12-helix terminated by the 4-pyridyl derivatives displayed remarkable porous metal-helix frameworks. Both head-to-tail intermolecular H-bonds of the 12-helix and metal ion coordination have played an important role in stabilizing the ordered metal-helix frameworks. The studies described here open the door to design a new class of metal-organic-frameworks from peptide foldamers.

Original languageEnglish
Pages (from-to)2251-2255
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number8
DOIs
StatePublished - 18 Feb 2019
Externally publishedYes

Keywords

  • X-ray diffraction
  • foldamers
  • frameworks
  • helices
  • metal coordination

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