Metabolite amyloid-like fibrils interact with model membranes

Shira Shaham-Niv; Pavel Rehak; Dor Zaguri; Sofiya Kolusheva; Petr Král; Ehud Gazit

doi:10.1039/c8cc01423j

Metabolite amyloid-like fibrils interact with model membranes

Shira Shaham-Niv, Pavel Rehak, Dor Zaguri, Sofiya Kolusheva, Petr Král, Ehud Gazit^*

^*Corresponding author for this work

Biotechnology

Research output: Contribution to journal › Article › peer-review

Abstract

Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

Original language	English
Pages (from-to)	4561-4564
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	36
DOIs	https://doi.org/10.1039/c8cc01423j
State	Published - 2018

Access to Document

10.1039/c8cc01423j

Cite this

@article{cc4373a320af412b98915bbfbd344055,

title = "Metabolite amyloid-like fibrils interact with model membranes",

abstract = "Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.",

author = "Shira Shaham-Niv and Pavel Rehak and Dor Zaguri and Sofiya Kolusheva and Petr Kr{\'a}l and Ehud Gazit",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2018.",

year = "2018",

doi = "10.1039/c8cc01423j",

language = "אנגלית",

volume = "54",

pages = "4561--4564",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "36",

}

TY - JOUR

T1 - Metabolite amyloid-like fibrils interact with model membranes

AU - Shaham-Niv, Shira

AU - Rehak, Pavel

AU - Zaguri, Dor

AU - Kolusheva, Sofiya

AU - Král, Petr

AU - Gazit, Ehud

PY - 2018

Y1 - 2018

N2 - Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

AB - Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

UR - http://www.scopus.com/inward/record.url?scp=85046408384&partnerID=8YFLogxK

U2 - 10.1039/c8cc01423j

DO - 10.1039/c8cc01423j

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:85046408384

SN - 1359-7345

VL - 54

SP - 4561

EP - 4564

JO - Chemical Communications

JF - Chemical Communications

IS - 36

ER -

Metabolite amyloid-like fibrils interact with model membranes

Abstract

Access to Document

Other files and links

Fingerprint

Cite this