Metabolite amyloid-like fibrils interact with model membranes

Shira Shaham-Niv, Pavel Rehak, Dor Zaguri, Sofiya Kolusheva, Petr Král, Ehud Gazit

Research output: Contribution to journalArticlepeer-review

Abstract

Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

Original languageEnglish
Pages (from-to)4561-4564
Number of pages4
JournalChemical Communications
Volume54
Issue number36
DOIs
StatePublished - 2018

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