Metabolite amyloid-like fibrils interact with model membranes

Shira Shaham-Niv, Pavel Rehak, Dor Zaguri, Sofiya Kolusheva, Petr Král, Ehud Gazit*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Amyloid-like structure formation by various metabolites represents a significant extension of the amyloidogenic building block family. Similar to protein amyloids, metabolite amyloids induce apoptotic toxicity, a process that was linked to membrane association. Here, we demonstrate that metabolite amyloids interact with model membranes and study the mechanism by molecular dynamics.

Original languageEnglish
Pages (from-to)4561-4564
Number of pages4
JournalChemical Communications
Issue number36
StatePublished - 2018


FundersFunder number
Adelis Forever Foundation
NSF Division of Materials Research1506886
Israel Science Foundation802/15


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