Metabolism of the Gram-Positive Bacterial Pathogen Listeria monocytogenes

John Demian Sauer, Anat A. Herskovits, Mary X.D. O'riordan

Research output: Contribution to journalArticlepeer-review

Abstract

Bacterial metabolism represents the biochemical space that bacteria can manipulate to produce energy, reducing equivalents and building blocks for replication. Gram-positive pathogens, such as Listeria monocytogenes, show remarkable flexibility, which allows for exploitation of diverse biological niches from the soil to the intracytosolic space. Although the human host represents a potentially rich source for nutrient acquisition, competition for nutrients with the host and hostile host defenses can constrain bacterial metabolism by various mechanisms, including nutrient sequestration. Here, we review metabolism in the model Gram-positive bacterium, L. monocytogenes, and highlight pathways that enable the replication, survival, and virulence of this bacterial pathogen.

Original languageEnglish
Article numberA20
JournalMicrobiology spectrum
Volume7
Issue number4
DOIs
StatePublished - Jul 2019

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