TY - JOUR
T1 - Metabolism of the Gram-Positive Bacterial Pathogen Listeria monocytogenes
AU - Sauer, John Demian
AU - Herskovits, Anat A.
AU - O'riordan, Mary X.D.
N1 - Publisher Copyright:
© 2019 American Society for Microbiology. All rights reserved.
PY - 2019/7
Y1 - 2019/7
N2 - Bacterial metabolism represents the biochemical space that bacteria can manipulate to produce energy, reducing equivalents and building blocks for replication. Gram-positive pathogens, such as Listeria monocytogenes, show remarkable flexibility, which allows for exploitation of diverse biological niches from the soil to the intracytosolic space. Although the human host represents a potentially rich source for nutrient acquisition, competition for nutrients with the host and hostile host defenses can constrain bacterial metabolism by various mechanisms, including nutrient sequestration. Here, we review metabolism in the model Gram-positive bacterium, L. monocytogenes, and highlight pathways that enable the replication, survival, and virulence of this bacterial pathogen.
AB - Bacterial metabolism represents the biochemical space that bacteria can manipulate to produce energy, reducing equivalents and building blocks for replication. Gram-positive pathogens, such as Listeria monocytogenes, show remarkable flexibility, which allows for exploitation of diverse biological niches from the soil to the intracytosolic space. Although the human host represents a potentially rich source for nutrient acquisition, competition for nutrients with the host and hostile host defenses can constrain bacterial metabolism by various mechanisms, including nutrient sequestration. Here, we review metabolism in the model Gram-positive bacterium, L. monocytogenes, and highlight pathways that enable the replication, survival, and virulence of this bacterial pathogen.
UR - http://www.scopus.com/inward/record.url?scp=85071570059&partnerID=8YFLogxK
U2 - 10.1128/microbiolspec.GPP3-0066-2019
DO - 10.1128/microbiolspec.GPP3-0066-2019
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C2 - 31418407
AN - SCOPUS:85071570059
VL - 7
JO - Microbiology spectrum
JF - Microbiology spectrum
SN - 2165-0497
IS - 4
M1 - A20
ER -