TY - JOUR
T1 - Metabolism disrupting chemicals and metabolic disorders
AU - Heindel, Jerrold J.
AU - Blumberg, Bruce
AU - Cave, Mathew
AU - Machtinger, Ronit
AU - Mantovani, Alberto
AU - Mendez, Michelle A.
AU - Nadal, Angel
AU - Palanza, Paola
AU - Panzica, Giancarlo
AU - Sargis, Robert
AU - Vandenberg, Laura N.
AU - vom Saal, Frederick
N1 - Publisher Copyright:
© 2016
PY - 2017/3/1
Y1 - 2017/3/1
N2 - The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these metabolic diseases. This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders. It will then specifically focus on the role of endocrine disrupting chemicals (EDCs) in the etiology of obesity, T2D and NAFLD while finally integrating the information on EDCs on multiple metabolic disorders that could lead to metabolic syndrome. We will specifically examine evidence linking EDC exposures during critical periods of development with metabolic diseases that manifest later in life and across generations.
AB - The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these metabolic diseases. This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders. It will then specifically focus on the role of endocrine disrupting chemicals (EDCs) in the etiology of obesity, T2D and NAFLD while finally integrating the information on EDCs on multiple metabolic disorders that could lead to metabolic syndrome. We will specifically examine evidence linking EDC exposures during critical periods of development with metabolic diseases that manifest later in life and across generations.
KW - Developmental origins of health and disease
KW - Diabetes
KW - Endocrine disruptors
KW - Lipid disorders
KW - Metabolism disruptors
KW - Obesity
KW - Obesogens
UR - http://www.scopus.com/inward/record.url?scp=85015801021&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2016.10.001
DO - 10.1016/j.reprotox.2016.10.001
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 27760374
AN - SCOPUS:85015801021
SN - 0890-6238
VL - 68
SP - 3
EP - 33
JO - Reproductive Toxicology
JF - Reproductive Toxicology
ER -
