Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chun Cheih Chao, Cristina Gutiérrez-Vázquez, Veit Rothhammer, Lior Mayo, Michael A. Wheeler, Emily C. Tjon, Stephanie E.J. Zandee, Manon Blain, Kalil Alves de Lima, Maisa C. Takenaka, Julian Avila-Pacheco, Patrick Hewson, Lei Liu, Liliana M. Sanmarco, Davis M. Borucki, Gabriel Z. Lipof, Sunia A. Trauger, Clary B. Clish, Jack P. Antel, Alexandre PratFrancisco J. Quintana

Research output: Contribution to journalArticlepeer-review

Abstract

By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.

Original languageEnglish
Pages (from-to)1483-1498.e22
JournalCell
Volume179
Issue number7
DOIs
StatePublished - 12 Dec 2019

Keywords

  • MAVS
  • Miglustat
  • NF-κB
  • astrocytes
  • cPLA2
  • lactate
  • lactosylceramide
  • metabolism
  • multiple sclerosis
  • neuroinflammation

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