Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chun Cheih Chao, Cristina Gutiérrez-Vázquez, Veit Rothhammer, Lior Mayo, Michael A. Wheeler, Emily C. Tjon, Stephanie E.J. Zandee, Manon Blain, Kalil Alves de Lima, Maisa C. Takenaka, Julian Avila-Pacheco, Patrick Hewson, Lei Liu, Liliana M. Sanmarco, Davis M. Borucki, Gabriel Z. Lipof, Sunia A. Trauger, Clary B. Clish, Jack P. Antel, Alexandre PratFrancisco J. Quintana*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.

Original languageEnglish
Pages (from-to)1483-1498.e22
JournalCell
Volume179
Issue number7
DOIs
StatePublished - 12 Dec 2019

Funding

FundersFunder number
MSSC
Mallinkrodt PharmaceuticalsA219074
National Institutes of HealthRG4111A1, JF2161-A-5
National Institute of Environmental Health SciencesR01ES025530
National Multiple Sclerosis Society104-2917-I-564 – 024
European Molecular Biology Organization
California Department of Fish and GameRO4866 1/1
Dana-Farber Cancer Institute5R24HD000836, T32CA207201, F32NS101790
Fundación Alfonso Martín EscuderoALTF 610-2017
Eunice Kennedy Shriver National Institute of Child Health and Human Development
Canadian Institutes of Health Research
Deutsche Forschungsgemeinschaft
Canada Research Chairs
Ministry of Science and Technology, Taiwan

    Keywords

    • MAVS
    • Miglustat
    • NF-κB
    • astrocytes
    • cPLA2
    • lactate
    • lactosylceramide
    • metabolism
    • multiple sclerosis
    • neuroinflammation

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