Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chun Cheih Chao; Cristina Gutiérrez-Vázquez; Veit Rothhammer; Lior Mayo; Michael A. Wheeler; Emily C. Tjon; Stephanie E.J. Zandee; Manon Blain; Kalil Alves de Lima; Maisa C. Takenaka; Julian Avila-Pacheco; Patrick Hewson; Lei Liu; Liliana M. Sanmarco; Davis M. Borucki; Gabriel Z. Lipof; Sunia A. Trauger; Clary B. Clish; Jack P. Antel; Alexandre Prat; Francisco J. Quintana

doi:10.1016/j.cell.2019.11.016

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Chun Cheih Chao, Cristina Gutiérrez-Vázquez, Veit Rothhammer, Lior Mayo, Michael A. Wheeler, Emily C. Tjon, Stephanie E.J. Zandee, Manon Blain, Kalil Alves de Lima, Maisa C. Takenaka, Julian Avila-Pacheco, Patrick Hewson, Lei Liu, Liliana M. Sanmarco, Davis M. Borucki, Gabriel Z. Lipof, Sunia A. Trauger, Clary B. Clish, Jack P. Antel, Alexandre PratFrancisco J. Quintana^*

^*Corresponding author for this work

Department of Cell Research and Immunology

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.

Original language	English
Pages (from-to)	1483-1498.e22
Journal	Cell
Volume	179
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2019.11.016
State	Published - 12 Dec 2019

Keywords

MAVS
Miglustat
NF-κB
astrocytes
cPLA2
lactate
lactosylceramide
metabolism
multiple sclerosis
neuroinflammation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cell.2019.11.016

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Chao, C. C., Gutiérrez-Vázquez, C., Rothhammer, V., Mayo, L., Wheeler, M. A., Tjon, E. C., Zandee, S. E. J., Blain, M., de Lima, K. A., Takenaka, M. C., Avila-Pacheco, J., Hewson, P., Liu, L., Sanmarco, L. M., Borucki, D. M., Lipof, G. Z., Trauger, S. A., Clish, C. B., Antel, J. P., ... Quintana, F. J. (2019). Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS. Cell, 179(7), 1483-1498.e22. https://doi.org/10.1016/j.cell.2019.11.016

@article{4b3083216dc9416aa8ae4519bcee86ca,

title = "Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS",

abstract = "By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.",

keywords = "MAVS, Miglustat, NF-κB, astrocytes, cPLA2, lactate, lactosylceramide, metabolism, multiple sclerosis, neuroinflammation",

author = "Chao, {Chun Cheih} and Cristina Guti{\'e}rrez-V{\'a}zquez and Veit Rothhammer and Lior Mayo and Wheeler, {Michael A.} and Tjon, {Emily C.} and Zandee, {Stephanie E.J.} and Manon Blain and {de Lima}, {Kalil Alves} and Takenaka, {Maisa C.} and Julian Avila-Pacheco and Patrick Hewson and Lei Liu and Sanmarco, {Liliana M.} and Borucki, {Davis M.} and Lipof, {Gabriel Z.} and Trauger, {Sunia A.} and Clish, {Clary B.} and Antel, {Jack P.} and Alexandre Prat and Quintana, {Francisco J.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = dec,

day = "12",

doi = "10.1016/j.cell.2019.11.016",

language = "אנגלית",

volume = "179",

pages = "1483--1498.e22",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "7",

}

Chao, CC, Gutiérrez-Vázquez, C, Rothhammer, V, Mayo, L, Wheeler, MA, Tjon, EC, Zandee, SEJ, Blain, M, de Lima, KA, Takenaka, MC, Avila-Pacheco, J, Hewson, P, Liu, L, Sanmarco, LM, Borucki, DM, Lipof, GZ, Trauger, SA, Clish, CB, Antel, JP, Prat, A & Quintana, FJ 2019, 'Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS', Cell, vol. 179, no. 7, pp. 1483-1498.e22. https://doi.org/10.1016/j.cell.2019.11.016

TY - JOUR

T1 - Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

AU - Chao, Chun Cheih

AU - Gutiérrez-Vázquez, Cristina

AU - Rothhammer, Veit

AU - Mayo, Lior

AU - Wheeler, Michael A.

AU - Tjon, Emily C.

AU - Zandee, Stephanie E.J.

AU - Blain, Manon

AU - de Lima, Kalil Alves

AU - Takenaka, Maisa C.

AU - Avila-Pacheco, Julian

AU - Hewson, Patrick

AU - Liu, Lei

AU - Sanmarco, Liliana M.

AU - Borucki, Davis M.

AU - Lipof, Gabriel Z.

AU - Trauger, Sunia A.

AU - Clish, Clary B.

AU - Antel, Jack P.

AU - Prat, Alexandre

AU - Quintana, Francisco J.

PY - 2019/12/12

Y1 - 2019/12/12

N2 - By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.

AB - By exploring the immunometabolic pathways that drive pro-inflammatory astrocyte activities, sphingolipid metabolism is identified as a promising therapeutic target in CNS inflammation.

KW - MAVS

KW - Miglustat

KW - NF-κB

KW - astrocytes

KW - cPLA2

KW - lactate

KW - lactosylceramide

KW - metabolism

KW - multiple sclerosis

KW - neuroinflammation

UR - http://www.scopus.com/inward/record.url?scp=85076153358&partnerID=8YFLogxK

U2 - 10.1016/j.cell.2019.11.016

DO - 10.1016/j.cell.2019.11.016

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AN - SCOPUS:85076153358

SN - 0092-8674

VL - 179

SP - 1483-1498.e22

JO - Cell

JF - Cell

IS - 7

ER -

Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS

Abstract

Keywords

UN SDGs

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