Metabolic control by insulin detemir in basal-bolus therapy: Treat-to-target study in children and adolescents with type 1 diabetes

Revital Nimri, Yael Lebenthal, Shlomit Shalitin, Hadasa Benzaquen, Sharon Demol, Moshe Phillip*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Objective: To assess the efficacy and safety of insulin detemir administered once vs. twice daily in children and adolescents with type 1 diabetes mellitus. Research Design: In this prospective, open-label, treat-to-target study, 37 patients [mean age 12.7±3yr; diabetes duration 4.2±3yr, hemoglobin A1c (HbA1c) 8.8±0.8%] were scheduled to receive insulin detemir once daily before breakfast, with pre-meal insulin aspart, for 16-20wk. Detemir dose titration algorithm was based on age-related target fasting blood glucose levels during 4-8wk. Patients achieving target range continued on once-daily detemir (Group A) if up-titration could not be done due to hypoglycemia patients were switched to twice-daily detemir (Group B). Results: Nineteen (51%) patients continued with once-daily detemir. HbA1c decreased significantly in both groups (A: -0.7%, p=0.02; B: -0.8%, p=0.004), without a significant difference between groups. The frequency of nocturnal hypoglycemic events/week decreased in both groups but a significant change was found only in Group A (10.9-2.7, p<0.05 vs. 8.7-5.8, NS), with no change in frequency of severe hypoglycemic episodes in either group. No significant differences were found between and within groups for body mass index-standard deviation score, insulin requirement or treatment satisfaction. Group B patients were significantly younger than Group A patients (11.5±2.3 vs.13.8±3.2yr, p=0.01), with a higher percentage in active puberty (50 vs. 11%, p=0.003). Conclusion: Since twice-daily determir showed no clinical advantage over once-daily detemir, it appears reasonable to commence all children on once-daily detemir, taking into consideration that younger children and those in active puberty may require twice-daily therapy ( number, NCT00542399).

Original languageEnglish
Pages (from-to)196-202
Number of pages7
JournalPediatric Diabetes
Issue number3
StatePublished - May 2013


  • Basal insulin analog
  • Basal-bolus intensive therapy
  • Once/twice daily
  • Pediatric


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