Mercury in traditional Tibetan medicine - Panacea or problem?

Sarah Sallon, T. Namdul, S. Dolma, P. Dorjee, D. Dolma, T. Sadutshang, P. Ever-Hadani, T. Bdolah-Abram, S. Apter, S. Almog, S. Roberts

Research output: Contribution to journalArticlepeer-review

Abstract

Symptoms of mercury toxicity, biochemical changes, and blood/urine mercury levels were evaluated in a small group of patients. Six patients attending Delek Hospital, Dharamsala, India, taking mercury-containing traditional Tibetan medicine (TTM) (Group I), were compared with three patients taking non-mercury containing TTM (Group II) and healthy volunteers (Group III). Quantitative estimation of mercury ingestion based on chemical analysis was compared with US regulatory standards. Results: Group I were significantly older (mean 55 years ± SE 6.4) range 26-69 years, than Group II (26.7 years ± SE 5) range 17-34 years and Group III (32.5 years ± SE 0.5) range 33-34 years (P = 0.05). Group I took TTM on average for 51 months and had a mean of 2.5 non-specific, mercury-related symptoms. Group I had higher mean diastolic pressures (85 mmHg) than Group II (73 mmHg) (P = 0.06) and more loose teeth. Mean daily mercury intake for Group I was 674 μg, estimated as 10 μg/kg per day. (Established reference dose for chronic oral exposure: 0.3 μg/kg per day.) Blood mercury levels were non-detectable, but mean urinary mercury levels for Group I were 67 μg/L (EPA levels <20 μg/L). Renal and liver function tests were not significantly different between groups and within normal clinical range. Conclusions: Prolonged ingestion of mercury containing TTM is associated with absent blood levels, but relatively high urinary levels. Further studies are needed to evaluate toxicity and therapeutic potential.

Original languageEnglish
Pages (from-to)405-412
Number of pages8
JournalHuman and Experimental Toxicology
Volume25
Issue number7
DOIs
StatePublished - Jul 2006
Externally publishedYes

Keywords

  • Mercury toxicity
  • Precious Pills
  • Tibetan medicine

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