Menopausal hot flushes, plasma calcitonin and beta-endorphin

Ron Tepper*, Joseph Pardo, Jardena Ovadia, Yoram Beyth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The association between plasma calcitonin and β-endorphin has been shown in various studies with analgesic and thermoregulatory effects. In the present study, we sought a similar association between those chemicals and physiological menopausal hot flush. Plasma calcitonin and β-endorphin levels were measured in 5 women in physiologic menopause who suffered from frequent episodes of hot flushes. An increase in plasma calcitonin levels was noted during the hot flushes, although it was not significant. In contrast, plasma β-endorphin levels fell significantly at onset of the hot flush, as compared to their levels 5-20 min earlier (p < 0.005), and rose 5-15 min following the hot flush episode.

Original languageEnglish
Pages (from-to)98-101
Number of pages4
JournalGynecologic and Obstetric Investigation
Issue number2
StatePublished - 1992
Externally publishedYes


  • Calcitonin
  • Hot flush
  • β-Endorphins


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