Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

Felix Sahm; Umut H. Toprak; Daniel Hübschmann; Kortine Kleinheinz; Ivo Buchhalter; Martin Sill; Damian Stichel; Matthias Schick; Melanie Bewerunge-Hudler; Daniel Schrimpf; Gelareh Zadeh; Ken Aldape; Christel Herold-Mende; Katja Beck; Ori Staszewski; Marco Prinz; Carmit Ben Harosh; Roland Eils; Dominik Sturm; David T.W. Jones; Stefan M. Pfister; Werner Paulus; Zvi Ram; Matthias Schlesner; Rachel Grossman; Andreas von Deimling

doi:10.1007/s00401-017-1715-9

Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

Felix Sahm^*, Umut H. Toprak, Daniel Hübschmann, Kortine Kleinheinz, Ivo Buchhalter, Martin Sill, Damian Stichel, Matthias Schick, Melanie Bewerunge-Hudler, Daniel Schrimpf, Gelareh Zadeh, Ken Aldape, Christel Herold-Mende, Katja Beck, Ori Staszewski, Marco Prinz, Carmit Ben Harosh, Roland Eils, Dominik Sturm, David T.W. JonesStefan M. Pfister, Werner Paulus, Zvi Ram, Matthias Schlesner, Rachel Grossman, Andreas von Deimling

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Letter › peer-review

Original language	English
Pages (from-to)	155-158
Number of pages	4
Journal	Acta Neuropathologica
Volume	134
Issue number	1
DOIs	https://doi.org/10.1007/s00401-017-1715-9
State	Published - 1 Jul 2017

Keywords

Meningioma
Mutational signatures
NF2
Radiation-induced tumors

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10.1007/s00401-017-1715-9

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Sahm, F., Toprak, U. H., Hübschmann, D., Kleinheinz, K., Buchhalter, I., Sill, M., Stichel, D., Schick, M., Bewerunge-Hudler, M., Schrimpf, D., Zadeh, G., Aldape, K., Herold-Mende, C., Beck, K., Staszewski, O., Prinz, M., Harosh, C. B., Eils, R., Sturm, D., ... von Deimling, A. (2017). Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature. Acta Neuropathologica, 134(1), 155-158. https://doi.org/10.1007/s00401-017-1715-9

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title = "Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature",

keywords = "Meningioma, Mutational signatures, NF2, Radiation-induced tumors",

author = "Felix Sahm and Toprak, {Umut H.} and Daniel H{\"u}bschmann and Kortine Kleinheinz and Ivo Buchhalter and Martin Sill and Damian Stichel and Matthias Schick and Melanie Bewerunge-Hudler and Daniel Schrimpf and Gelareh Zadeh and Ken Aldape and Christel Herold-Mende and Katja Beck and Ori Staszewski and Marco Prinz and Harosh, {Carmit Ben} and Roland Eils and Dominik Sturm and Jones, {David T.W.} and Pfister, {Stefan M.} and Werner Paulus and Zvi Ram and Matthias Schlesner and Rachel Grossman and {von Deimling}, Andreas",

note = "Funding Information: We thank H-Y Nguyen, L D{\"o}rner, J Baron, K Lindenberg, U Lass, and J Meyer for skillful technical assistance and the Genome and Proteome Core Facility, High-Throughput Sequencing Unit of the DKFZ. This work was supported by the German Cancer Aid (110670, 110983), the Else Kr{\"o}ner-Fresenius Foundation (A_60), the DKFZ-HIPO through H033, the Hartmut Hoffmann-Berling International Graduate School (DH), the MD/PhD-program of the University Heidelberg (DH), and the Helmholtz International Graduate School for Cancer Research (UHT).",

year = "2017",

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doi = "10.1007/s00401-017-1715-9",

language = "אנגלית",

volume = "134",

pages = "155--158",

journal = "Acta Neuropathologica",

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Sahm, F, Toprak, UH, Hübschmann, D, Kleinheinz, K, Buchhalter, I, Sill, M, Stichel, D, Schick, M, Bewerunge-Hudler, M, Schrimpf, D, Zadeh, G, Aldape, K, Herold-Mende, C, Beck, K, Staszewski, O, Prinz, M, Harosh, CB, Eils, R, Sturm, D, Jones, DTW, Pfister, SM, Paulus, W, Ram, Z, Schlesner, M, Grossman, R & von Deimling, A 2017, 'Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature', Acta Neuropathologica, vol. 134, no. 1, pp. 155-158. https://doi.org/10.1007/s00401-017-1715-9

TY - JOUR

T1 - Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

AU - Sahm, Felix

AU - Toprak, Umut H.

AU - Hübschmann, Daniel

AU - Kleinheinz, Kortine

AU - Buchhalter, Ivo

AU - Sill, Martin

AU - Stichel, Damian

AU - Schick, Matthias

AU - Bewerunge-Hudler, Melanie

AU - Schrimpf, Daniel

AU - Zadeh, Gelareh

AU - Aldape, Ken

AU - Herold-Mende, Christel

AU - Beck, Katja

AU - Staszewski, Ori

AU - Prinz, Marco

AU - Harosh, Carmit Ben

AU - Eils, Roland

AU - Sturm, Dominik

AU - Jones, David T.W.

AU - Pfister, Stefan M.

AU - Paulus, Werner

AU - Ram, Zvi

AU - Schlesner, Matthias

AU - Grossman, Rachel

AU - von Deimling, Andreas

N1 - Funding Information: We thank H-Y Nguyen, L Dörner, J Baron, K Lindenberg, U Lass, and J Meyer for skillful technical assistance and the Genome and Proteome Core Facility, High-Throughput Sequencing Unit of the DKFZ. This work was supported by the German Cancer Aid (110670, 110983), the Else Kröner-Fresenius Foundation (A_60), the DKFZ-HIPO through H033, the Hartmut Hoffmann-Berling International Graduate School (DH), the MD/PhD-program of the University Heidelberg (DH), and the Helmholtz International Graduate School for Cancer Research (UHT).

PY - 2017/7/1

Y1 - 2017/7/1

KW - Meningioma

KW - Mutational signatures

KW - NF2

KW - Radiation-induced tumors

UR - http://www.scopus.com/inward/record.url?scp=85018778029&partnerID=8YFLogxK

U2 - 10.1007/s00401-017-1715-9

DO - 10.1007/s00401-017-1715-9

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C2 - 28474103

AN - SCOPUS:85018778029

SN - 0001-6322

VL - 134

SP - 155

EP - 158

JO - Acta Neuropathologica

JF - Acta Neuropathologica

IS - 1

ER -

Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

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