Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice

Irit Gordon, Ettie Grauer, Idit Genis, Ephraim Sehayek, Daniel M. Michaelson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

191 Scopus citations


Apolipoprotein E-deficient mice provide a useful system for studying the role of apolipoprotein E (apoE) in the function of distinct neuronal systems. In the present study we focused on the cholinergic system of these mice. This was pursued by measurements of specific biochemical, physiological and cognitive parameters. Morris Water Maze tasks revealed impairments in working memory but not in reference memory of the apoE-deficient mice. Measurements of brain choline acetyltransferase activities revealed them to be markedly lower in the hippocampus and frontal cortex of the apoE-deficient mice than in the corresponding brain areas of the controls, but unaltered in other brain areas. In addition, hypothermia induced by the centrally acting muscarinic agonist, oxotremorine, was reduced in the apoE-deficient mice as compared to controls. These results show that apoE-deficient mice have cholinergic deficits and highlight the importance of this mouse model for studying the interactions between apoE and the cholinergic nervous system.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalNeuroscience Letters
Issue number1
StatePublished - 13 Oct 1995


FundersFunder number
BUPA Medical Foundation
Harold Hyam Wingate Foundation


    • Apolipoprotein E
    • Cholinergic nervous system
    • Memory
    • Mice


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