Memdock: An α-Helical Membrane Protein Docking Algorithm

Naama Hurwitz, Haim J. Wolfson

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Memdock is a tool for docking α-helical membrane proteins which takes into consideration the lipid bilayer environment. Given two α-helical membrane located protein molecules, the method outputs a list of potential complexes sorted by energy criteria. The program includes three steps: docking, refinement, and re-ranking of the results. All three docking steps have been customized to the membrane environment in order to improve performance and reduce program run-time. In this chapter, we describe the application of our web server, referred to as Memdock, for prediction of the docking complex for a pair of input membrane protein structures. Memdock is freely available for academic users without registration at http://bioinfo3d.cs.tau.ac.il/Memdock/index.html.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages111-117
Number of pages7
DOIs
StatePublished - 2021

Publication series

NameMethods in Molecular Biology
Volume2315
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Lipid bilayer
  • Membrane proteins
  • Protein–protein docking

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