TY - JOUR
T1 - Membrane mobility agents
T2 - Alteration of human red blood cell membrane properties
AU - Kosower, Nechama S.
AU - Zipser, Yehudit
AU - Kosower, Edward M.
N1 - Funding Information:
This research was supported by a grant from the United States-Israel Binational Science Foundation (BSF), Jerusalem, Israel.
PY - 1980
Y1 - 1980
N2 - Brief incubation of human red cells with the membrane mobility agent, 2-(2-methoxy)-ethoxyethyl 8-(2-n-octylcyclopropyl)-octanoate (A2C), produces stomatocytes (with invaginations) along with a decrease in osmotic fragility, an altered distribution in a two-phase dextran-polyethylene glycol-water system, and increased permeability to the GSH oxidant, the diazene derivative, 1,2-diazenedicarboxylic acid bis(N′-methylpiperazide). These changes are consistent with what would be expected for agents which increase membrane lipid disorder. Membrane mobility agents provide a very convenient means for altering membrane properties and should be useful for studies on both normal and abnormal red cells.
AB - Brief incubation of human red cells with the membrane mobility agent, 2-(2-methoxy)-ethoxyethyl 8-(2-n-octylcyclopropyl)-octanoate (A2C), produces stomatocytes (with invaginations) along with a decrease in osmotic fragility, an altered distribution in a two-phase dextran-polyethylene glycol-water system, and increased permeability to the GSH oxidant, the diazene derivative, 1,2-diazenedicarboxylic acid bis(N′-methylpiperazide). These changes are consistent with what would be expected for agents which increase membrane lipid disorder. Membrane mobility agents provide a very convenient means for altering membrane properties and should be useful for studies on both normal and abnormal red cells.
UR - http://www.scopus.com/inward/record.url?scp=0019292124&partnerID=8YFLogxK
U2 - 10.1016/0003-9861(80)90183-6
DO - 10.1016/0003-9861(80)90183-6
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AN - SCOPUS:0019292124
SN - 0003-9861
VL - 203
SP - 325
EP - 331
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
IS - 1
ER -