Membrane mobility agents: Alteration of human red blood cell membrane properties

Nechama S. Kosower*, Yehudit Zipser, Edward M. Kosower

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Brief incubation of human red cells with the membrane mobility agent, 2-(2-methoxy)-ethoxyethyl 8-(2-n-octylcyclopropyl)-octanoate (A2C), produces stomatocytes (with invaginations) along with a decrease in osmotic fragility, an altered distribution in a two-phase dextran-polyethylene glycol-water system, and increased permeability to the GSH oxidant, the diazene derivative, 1,2-diazenedicarboxylic acid bis(N′-methylpiperazide). These changes are consistent with what would be expected for agents which increase membrane lipid disorder. Membrane mobility agents provide a very convenient means for altering membrane properties and should be useful for studies on both normal and abnormal red cells.

Original languageEnglish
Pages (from-to)325-331
Number of pages7
JournalArchives of Biochemistry and Biophysics
Volume203
Issue number1
DOIs
StatePublished - 1980

Funding

FundersFunder number
United States-Israel Binational Science Foundation

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