@article{509fc42b3826405f97d73e041f3a265e,
title = "Membrane fluidization triggers membrane remodeling which affects the thermotolerance in Escherichia coli",
abstract = "Treatment of Escherichia coli with non-lethal doses of heat or benzyl alcohol (BA) causes transient membrane fluidization and permeabilization, and induces the rapid transcription of heat-shock genes in a σ32- dependent manner. This early response is followed by a rapid adaptation (priming) of the cells to otherwise lethal elevated temperature, in strong correlation with an observed remodeling of the composition and alkyl chain unsaturation of membrane lipids. The acquisition of cellular thermotolerance in BA-primed cells is unrelated to protein denaturation and is not accompanied by the formation of major heat-shock proteins, such as GroEL and DnaK. This suggests that the rapid remodeling of membrane composition is sufficient for the short-term bacterial thermotolerance.",
keywords = "Acquired thermotolerance, Heat stress, Lipid saturation, Membrane fluidity, Molecular chaperones, Thermosensor",
author = "Natalia Shigapova and Zsolt T{\"o}r{\"o}k and G{\'a}bor Balogh and Pierre Goloubinoff and L{\'a}szl{\'o} V{\'i}gh and Ibolya Horv{\'a}th",
note = "Funding Information: We thank E. Ron for Homoserine trans -succinylase antibodies and A. Farina for technical support. This work was supported by grants from the Hungarian National Scientific Research Foundation (OTKA: TS 044836 and T 038334).",
year = "2005",
month = mar,
day = "25",
doi = "10.1016/j.bbrc.2005.01.081",
language = "אנגלית",
volume = "328",
pages = "1216--1223",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Elsevier B.V.",
number = "4",
}