@article{967b3a9b8e8c4f69aeef2f011a76be92,
title = "Membrane fission by dynamin: what we know and what we need to know",
abstract = "The large GTPase dynamin is the first protein shown to catalyze membrane fission. Dynamin and its related proteins are essential to many cell functions, from endocytosis to organelle division and fusion, and it plays a critical role in many physiological functions such as synaptic transmission and muscle contraction. Research of the past three decades has focused on understanding how dynamin works. In this review, we present the basis for an emerging consensus on how dynamin functions. Three properties of dynamin are strongly supported by experimental data: first, dynamin oligomerizes into a helical polymer; second, dynamin oligomer constricts in the presence of GTP; and third, dynamin catalyzes membrane fission upon GTP hydrolysis. We present the two current models for fission, essentially diverging in how GTP energy is spent. We further discuss how future research might solve the remaining open questions presently under discussion.",
keywords = "GTPase, dynamin, endocytosis, membrane fission, molecular motor",
author = "Bruno Antonny and Christopher Burd and {De Camilli}, Pietro and Elizabeth Chen and Oliver Daumke and Katja Faelber and Marijn Ford and Frolov, {Vadim A.} and Adam Frost and Hinshaw, {Jenny E.} and Tom Kirchhausen and Kozlov, {Michael M.} and Martin Lenz and Low, {Harry H.} and Harvey McMahon and Christien Merrifield and Pollard, {Thomas D.} and Robinson, {Phillip J.} and Aur{\'e}lien Roux and Sandra Schmid",
note = "Publisher Copyright: {\textcopyright} 2016 The Authors. Published under the terms of the CC BY NC ND 4.0 license",
year = "2016",
month = nov,
day = "2",
doi = "10.15252/embj.201694613",
language = "אנגלית",
volume = "35",
pages = "2270--2284",
journal = "EMBO Journal",
issn = "0261-4189",
publisher = "Springer Science and Business Media Deutschland GmbH",
number = "21",
}