Membrane Curvature in Synaptic Vesicle Fusion and Beyond

Harvey T. McMahon; Michael M. Kozlov; Sascha Martens

doi:10.1016/j.cell.2010.02.017

Membrane Curvature in Synaptic Vesicle Fusion and Beyond

Harvey T. McMahon^*, Michael M. Kozlov, Sascha Martens

^*Corresponding author for this work

Physiology Pharmacology

Research output: Contribution to journal › Short survey › peer-review

176 Scopus citations

Abstract

Recent evidence suggests that the Ca²⁺-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.

Original language	English
Pages (from-to)	601-605
Number of pages	5
Journal	Cell
Volume	140
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2010.02.017
State	Published - 5 Mar 2010

Funding

Funders	Funder number
Medical Research Council	MC_U105178795

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10.1016/j.cell.2010.02.017

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title = "Membrane Curvature in Synaptic Vesicle Fusion and Beyond",

abstract = "Recent evidence suggests that the Ca2+-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.",

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AU - Kozlov, Michael M.

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AB - Recent evidence suggests that the Ca2+-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.

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Membrane Curvature in Synaptic Vesicle Fusion and Beyond

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