TY - JOUR
T1 - Melatonin rhythms in stroke patients
AU - Beloosesky, Yichayaou
AU - Grinblat, Josef
AU - Laudon, Moshe
AU - Grosman, Boris
AU - Streifler, Jonathan Y.
AU - Zisapel, Nava
PY - 2002/2/15
Y1 - 2002/2/15
N2 - Very little is known regarding melatonin's circadian rhythm in stroke patients. We compared urinary-sulfatoxymelatonin (6-SMT), its major metabolite, in 11 extensive cortical and seven deep or lacunar stroke patients on day 3 or 4 and day 10 post-stroke. Urinary 6-SMT and creatinine measured every 4 h for 24 h starting at 06:00 h significantly fluctuated during the day in both types of stroke and did not differ between day 3 or 4 and day 10 post-stroke. However, in extensive cortical lesions, a delay in the 6-SMT excretion was observed in the first post-stroke days compared to day 10. We conclude that circadian oscillator is preserved in extensive cortical as well as in deep and lacunar strokes. Extensive cortical stroke might delay the melatonin surge during the first post-stroke days.
AB - Very little is known regarding melatonin's circadian rhythm in stroke patients. We compared urinary-sulfatoxymelatonin (6-SMT), its major metabolite, in 11 extensive cortical and seven deep or lacunar stroke patients on day 3 or 4 and day 10 post-stroke. Urinary 6-SMT and creatinine measured every 4 h for 24 h starting at 06:00 h significantly fluctuated during the day in both types of stroke and did not differ between day 3 or 4 and day 10 post-stroke. However, in extensive cortical lesions, a delay in the 6-SMT excretion was observed in the first post-stroke days compared to day 10. We conclude that circadian oscillator is preserved in extensive cortical as well as in deep and lacunar strokes. Extensive cortical stroke might delay the melatonin surge during the first post-stroke days.
KW - Circadian rhythm
KW - Cortical stroke
KW - Melatonin
KW - Urinary-sulfatoxymelatonin
UR - http://www.scopus.com/inward/record.url?scp=0037083212&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(01)02568-X
DO - 10.1016/S0304-3940(01)02568-X
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AN - SCOPUS:0037083212
SN - 0304-3940
VL - 319
SP - 103
EP - 106
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -