Melatonin receptors revisited

Nava Zisapel*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


The pineal gland and its major product melatonin have a key role in conveying the environmental photoperiodic stimuli that impinge upon the mammalian reproductive axis. The brain, especially the medial preoptic and suprachiasmatic areas are thought to be the main sites of melatonin's neuroendocrine activity. The responsiveness of the mammalian reproductive system to the hormone is dependent on age, on the prevailing cyclical stage and on the circadian time. The existence of specific125I-melatonin binding sites in synaptosomal fractions from rodent brain has recently been reported. The binding of125I-melatonin is inhibited by melatonin and by the novel melatonin antagonist ML-23 but not by dopamine, serotonin or other structurally related compounds. The densities of125I-melatonin binding sites at discrete brain regions vary significantly with age, circulating levels of steroid hormones or circadian time. These phenomena are compatible with the existence of melatonin receptors in the brain.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalJournal of Neural Transmission
Issue number1
StatePublished - Feb 1988


Dive into the research topics of 'Melatonin receptors revisited'. Together they form a unique fingerprint.

Cite this