Melatonin and schizophrenia

Yoram Barak, Dov Aizenberg

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


In recent years the spectrum of known effects of melatonin was reported to exceed by far the original discoveries. Melatonin regulates, circadian and seasonal rhythms, such as the sleep-wake cycle and acts as an immunostimulator and cytoprotective agent. The association between melatonin and schizophrenia has been studied in several clinical domains such as sleep, cognition and tardive dyskinesia. The presumed pathophysiology and mechanism is thought to be related to the regulation of central dopaminergic pathways. In addition, recent clinical and research data indicates that melatonin may be advantageous as a complementary intervention for sleep disturbances of schizophrenia patients and possibly for patients suffering from tardive dyskinesia.

Original languageEnglish
Title of host publicationNew Hope for Mental Disturbances
PublisherNova Science Publishers, Inc.
Number of pages8
ISBN (Electronic)9781614703624
ISBN (Print)9781606926918
StatePublished - 1 Jan 2009


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