TY - JOUR
T1 - Melatonin and mental capacities in newborn infants
AU - Ferber, Sari Goldstein
AU - Als, Heidelise
AU - McAnulty, Gloria
AU - Peretz, Hava
AU - Zisapel, Nava
N1 - Funding Information:
Supported by the BiNational American Israeli Science Foundation and the Fulbright New Century Scholars Award (to S.G.F.). The authors declare no conflicts of interest.
PY - 2011/7
Y1 - 2011/7
N2 - Objectives: To investigate the role of melatonin in the emergence of mental capacities in the newborn infant. Study design: Assessment of Preterm Infant Behavior examination was performed at 2 weeks post-term age for 39 (21 preterm and 18 term) infants. 6-Suphatoxymelatonin from nocturnal urine samples was analyzed by enzyme-linked immunosorbent assays, and the Mental Developmental Index, assessed by Bayley scales, was correlated at 4, 6, and 9 months' corrected age. Results: Multivariate analysis of variance with repeated measures showed that improved autonomic function at 2 weeks of age was associated with higher Mental Developmental Index scores at 9 months when related to the amount of melatonin at 4, 6, and 9 months of age. Conclusions: Early compromised autonomic system function in preterm infants is associated with lower mental capacities and is related to lower melatonin levels at later ages.
AB - Objectives: To investigate the role of melatonin in the emergence of mental capacities in the newborn infant. Study design: Assessment of Preterm Infant Behavior examination was performed at 2 weeks post-term age for 39 (21 preterm and 18 term) infants. 6-Suphatoxymelatonin from nocturnal urine samples was analyzed by enzyme-linked immunosorbent assays, and the Mental Developmental Index, assessed by Bayley scales, was correlated at 4, 6, and 9 months' corrected age. Results: Multivariate analysis of variance with repeated measures showed that improved autonomic function at 2 weeks of age was associated with higher Mental Developmental Index scores at 9 months when related to the amount of melatonin at 4, 6, and 9 months of age. Conclusions: Early compromised autonomic system function in preterm infants is associated with lower mental capacities and is related to lower melatonin levels at later ages.
UR - http://www.scopus.com/inward/record.url?scp=79958748179&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2010.12.032
DO - 10.1016/j.jpeds.2010.12.032
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AN - SCOPUS:79958748179
SN - 0022-3476
VL - 159
SP - 99-103.e1
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 1
ER -