Meeting report: Summary of IARC Monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol

Vincent James Cogliano; Yann Grosse; Robert A. Baan; Kurt Straif; Marie Béatrice Secretan; Fatiha El Ghissassi; Ulrich Andrae; Sherwood Burge; Rajendra Chhabra; John Cocker; David Coggon; Rory Conolly; Paul Demers; David Eastmond; Elaine Faustman; Victor Feron; Michel Gérin; Marcel Goldberg; Bernard Goldstein; Roland Grafström; Johnni Hansen; Michael Hauptmann; Kathy Hughes; Ted Junghans; Dan Krewski; Steve Olin; Martine Reynier; Judith Shaham; Morando Soffritti; Leslie Stayner; Patricia Stewart; Douglas Wolf

doi:10.1289/ehp.7542

Meeting report: Summary of IARC Monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol

Vincent James Cogliano^*
, Yann Grosse
, Robert A. Baan
, Kurt Straif
, Marie Béatrice Secretan
, Fatiha El Ghissassi
, Ulrich Andrae
, Sherwood Burge
, Rajendra Chhabra
, John Cocker
, David Coggon
, Rory Conolly
, Paul Demers
, David Eastmond
, Elaine Faustman
, Victor Feron
, Michel Gérin
, Marcel Goldberg
, Bernard Goldstein
, Roland Grafström

Johnni Hansen, Michael Hauptmann, Kathy Hughes, Ted Junghans, Dan Krewski, Steve Olin, Martine Reynier, Judith Shaham, Morando Soffritti, Leslie Stayner, Patricia Stewart, Douglas Wolf

^*Corresponding author for this work

School of Public Health

International Agency for Research on Cancer

Research output: Contribution to journal › Review article › peer-review

343 Scopus citations

Abstract

An international, interdisciplinary working group of expert scientists met in June 2004 to develop IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Each IARC Monograph includes a critical review of the pertinent scientific literature and an evaluation of an agent's potential to cause cancer in humans. After a thorough discussion of the epidemiologic, experimental, and other relevant data, the working group concluded that formaldehyde is carcinogenic to humans, based on sufficient evidence in humans and in experimental animals. In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, "strong but not sufficient" evidence of leukemia, and limited evidence of sinonasal cancer. The working group also concluded that 2-butoxyethanol and 1-tert-butoxy-2-propanol are not classifiable as to their carcinogenicity to humans, each having limited evidence in experimental animals and inadequate evidence in humans. These three evaluations and the supporting data will be- published as Volume 88 of the IARC Monographs.

Original language	English
Pages (from-to)	1205-1208
Number of pages	4
Journal	Environmental Health Perspectives
Volume	113
Issue number	9
DOIs	https://doi.org/10.1289/ehp.7542
State	Published - Sep 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

1-tert-butoxy-2-propanol
2-butoxyethanol
Carcinogen
Formaldehyde
Glycol ethers
Hazard identification
IARC Monographs
Leukemia
Nasopharyngeal cancer
Sinonasal cancer

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10.1289/ehp.7542

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Cogliano, V. J., Grosse, Y., Baan, R. A., Straif, K., Secretan, M. B., El Ghissassi, F., Andrae, U., Burge, S., Chhabra, R., Cocker, J., Coggon, D., Conolly, R., Demers, P., Eastmond, D., Faustman, E., Feron, V., Gérin, M., Goldberg, M., Goldstein, B., ... Wolf, D. (2005). Meeting report: Summary of IARC Monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Environmental Health Perspectives, 113(9), 1205-1208. https://doi.org/10.1289/ehp.7542

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abstract = "An international, interdisciplinary working group of expert scientists met in June 2004 to develop IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Each IARC Monograph includes a critical review of the pertinent scientific literature and an evaluation of an agent's potential to cause cancer in humans. After a thorough discussion of the epidemiologic, experimental, and other relevant data, the working group concluded that formaldehyde is carcinogenic to humans, based on sufficient evidence in humans and in experimental animals. In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, {"}strong but not sufficient{"} evidence of leukemia, and limited evidence of sinonasal cancer. The working group also concluded that 2-butoxyethanol and 1-tert-butoxy-2-propanol are not classifiable as to their carcinogenicity to humans, each having limited evidence in experimental animals and inadequate evidence in humans. These three evaluations and the supporting data will be- published as Volume 88 of the IARC Monographs.",

keywords = "1-tert-butoxy-2-propanol, 2-butoxyethanol, Carcinogen, Formaldehyde, Glycol ethers, Hazard identification, IARC Monographs, Leukemia, Nasopharyngeal cancer, Sinonasal cancer",

author = "Cogliano, \{Vincent James\} and Yann Grosse and Baan, \{Robert A.\} and Kurt Straif and Secretan, \{Marie B{\'e}atrice\} and \{El Ghissassi\}, Fatiha and Ulrich Andrae and Sherwood Burge and Rajendra Chhabra and John Cocker and David Coggon and Rory Conolly and Paul Demers and David Eastmond and Elaine Faustman and Victor Feron and Michel G{\'e}rin and Marcel Goldberg and Bernard Goldstein and Roland Grafstr{\"o}m and Johnni Hansen and Michael Hauptmann and Kathy Hughes and Ted Junghans and Dan Krewski and Steve Olin and Martine Reynier and Judith Shaham and Morando Soffritti and Leslie Stayner and Patricia Stewart and Douglas Wolf",

year = "2005",

month = sep,

doi = "10.1289/ehp.7542",

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Cogliano, VJ, Grosse, Y, Baan, RA, Straif, K, Secretan, MB, El Ghissassi, F, Andrae, U, Burge, S, Chhabra, R, Cocker, J, Coggon, D, Conolly, R, Demers, P, Eastmond, D, Faustman, E, Feron, V, Gérin, M, Goldberg, M, Goldstein, B, Grafström, R, Hansen, J, Hauptmann, M, Hughes, K, Junghans, T, Krewski, D, Olin, S, Reynier, M, Shaham, J, Soffritti, M, Stayner, L, Stewart, P & Wolf, D 2005, 'Meeting report: Summary of IARC Monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol', Environmental Health Perspectives, vol. 113, no. 9, pp. 1205-1208. https://doi.org/10.1289/ehp.7542

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AU - Straif, Kurt

AU - Secretan, Marie Béatrice

AU - El Ghissassi, Fatiha

AU - Andrae, Ulrich

AU - Burge, Sherwood

AU - Chhabra, Rajendra

AU - Cocker, John

AU - Coggon, David

AU - Conolly, Rory

AU - Demers, Paul

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AU - Goldstein, Bernard

AU - Grafström, Roland

AU - Hansen, Johnni

AU - Hauptmann, Michael

AU - Hughes, Kathy

AU - Junghans, Ted

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AU - Reynier, Martine

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Meeting report: Summary of IARC Monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol

Abstract

UN SDGs

Keywords

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