Meeting report: Summary of IARC Monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol

Vincent James Cogliano*, Yann Grosse, Robert A. Baan, Kurt Straif, Marie Béatrice Secretan, Fatiha El Ghissassi, Ulrich Andrae, Sherwood Burge, Rajendra Chhabra, John Cocker, David Coggon, Rory Conolly, Paul Demers, David Eastmond, Elaine Faustman, Victor Feron, Michel Gérin, Marcel Goldberg, Bernard Goldstein, Roland GrafströmJohnni Hansen, Michael Hauptmann, Kathy Hughes, Ted Junghans, Dan Krewski, Steve Olin, Martine Reynier, Judith Shaham, Morando Soffritti, Leslie Stayner, Patricia Stewart, Douglas Wolf

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


An international, interdisciplinary working group of expert scientists met in June 2004 to develop IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans (IARC Monographs) on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol. Each IARC Monograph includes a critical review of the pertinent scientific literature and an evaluation of an agent's potential to cause cancer in humans. After a thorough discussion of the epidemiologic, experimental, and other relevant data, the working group concluded that formaldehyde is carcinogenic to humans, based on sufficient evidence in humans and in experimental animals. In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, "strong but not sufficient" evidence of leukemia, and limited evidence of sinonasal cancer. The working group also concluded that 2-butoxyethanol and 1-tert-butoxy-2-propanol are not classifiable as to their carcinogenicity to humans, each having limited evidence in experimental animals and inadequate evidence in humans. These three evaluations and the supporting data will be- published as Volume 88 of the IARC Monographs.

Original languageEnglish
Pages (from-to)1205-1208
Number of pages4
JournalEnvironmental Health Perspectives
Issue number9
StatePublished - Sep 2005


  • 1-tert-butoxy-2-propanol
  • 2-butoxyethanol
  • Carcinogen
  • Formaldehyde
  • Glycol ethers
  • Hazard identification
  • IARC Monographs
  • Leukemia
  • Nasopharyngeal cancer
  • Sinonasal cancer


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