TY - JOUR
T1 - Medication use in Alzheimer's disease and healthy aging
T2 - Results from a research registry
AU - Mizrahi, Eli H.
AU - Fritsch, Thomas
AU - Geldmacher, David S.
AU - Geldmacher, S.
AU - Soas, Amir H.
AU - Friedland, Robert P.
AU - Lerner, Alan J.
N1 - Funding Information:
This study was partly supported by NIA/NIH (P50-AG08012); the Nickman Family, Cleveland, OH; Mandel Foundation, Cleveland, OH; Alzheimer Association, Chicago, IL; Philip Morris, USA; Institution for the Study of Aging, NY, and the American Physicians Fellowship for Medicine in Israel. Presented in part at the World Alzheimer Congress, Washington, DC, July 2000.
PY - 2002
Y1 - 2002
N2 - The purpose of this research was to determine if decreased utilization of specific medication in individuals with Alzheimer's disease (AD) reflects a global process of decreased medication usage. Participants were 1103 individuals (461 controls; 437 probable AD; 161 possible AD, and 44 Mixed Dementia), drawn from our Alzheimer's Disease Research Registry. Medication usage at entry into the registry did not differ between controls and probable AD cases. Possible AD and the mixed dementia cases took significantly more medications than controls or probable AD cases. Longitudinal analysis showed no significant changes in controls and mixed dementia cases up to 2 years, and use increased in possible and probable AD cases over time. Stratification of subjects by MMSE scores at entry showed no significant difference between groups. Medication use in probable AD patients does not differ from controls, and does not seem to be subject to systematic bias based on disease progression (as measured by MMSE scores). The presence of co-morbidity adds to medication utilization. Cognitive impairment does not appear to affect total medication use, suggesting that specific medication utilization patterns are unlikely to be the result of larger usage patterns.
AB - The purpose of this research was to determine if decreased utilization of specific medication in individuals with Alzheimer's disease (AD) reflects a global process of decreased medication usage. Participants were 1103 individuals (461 controls; 437 probable AD; 161 possible AD, and 44 Mixed Dementia), drawn from our Alzheimer's Disease Research Registry. Medication usage at entry into the registry did not differ between controls and probable AD cases. Possible AD and the mixed dementia cases took significantly more medications than controls or probable AD cases. Longitudinal analysis showed no significant changes in controls and mixed dementia cases up to 2 years, and use increased in possible and probable AD cases over time. Stratification of subjects by MMSE scores at entry showed no significant difference between groups. Medication use in probable AD patients does not differ from controls, and does not seem to be subject to systematic bias based on disease progression (as measured by MMSE scores). The presence of co-morbidity adds to medication utilization. Cognitive impairment does not appear to affect total medication use, suggesting that specific medication utilization patterns are unlikely to be the result of larger usage patterns.
KW - Activities of daily living
KW - Alzheimer's disease
KW - Drug utilization
UR - http://www.scopus.com/inward/record.url?scp=0036292744&partnerID=8YFLogxK
U2 - 10.1300/J018v24n01_06
DO - 10.1300/J018v24n01_06
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AN - SCOPUS:0036292744
SN - 0731-7115
VL - 24
SP - 75
EP - 84
JO - Clinical Gerontologist
JF - Clinical Gerontologist
IS - 1-2
ER -