TY - JOUR
T1 - Medication-related osteonecrosis of the jaws associated with intravitreal administration of ranibizumab
AU - Oz, I.
AU - Kaplan, I.
AU - Kleinman, S.
AU - Arbel, S.
AU - Shuster, A.
N1 - Publisher Copyright:
© 2020 International Association of Oral and Maxillofacial Surgeons
PY - 2020/12
Y1 - 2020/12
N2 - Medication-related osteonecrosis of the jaws (MRONJ) is a well-known complication that, in the majority of cases, is related to antiresorptive agents. Numerous articles have described cases of MRONJ in bisphosphonate-naïve patients treated with anti-angiogenic agents administered via various routes. A single case of MRONJ after intravitreal injection of bevacizumab has been reported. We report a case of MRONJ after intravitreal injection of a different anti-angiogenic agent – ranibizumab – for the treatment of neovascular age-related macular degeneration, in a bisphosphonate-naïve patient. Although it may be a rare complication, patients treated with multiple doses of anti-angiogenic agents should be monitored for the possible early diagnosis of MRONJ.
AB - Medication-related osteonecrosis of the jaws (MRONJ) is a well-known complication that, in the majority of cases, is related to antiresorptive agents. Numerous articles have described cases of MRONJ in bisphosphonate-naïve patients treated with anti-angiogenic agents administered via various routes. A single case of MRONJ after intravitreal injection of bevacizumab has been reported. We report a case of MRONJ after intravitreal injection of a different anti-angiogenic agent – ranibizumab – for the treatment of neovascular age-related macular degeneration, in a bisphosphonate-naïve patient. Although it may be a rare complication, patients treated with multiple doses of anti-angiogenic agents should be monitored for the possible early diagnosis of MRONJ.
KW - Anti-angiogenic agent
KW - MRONJ
KW - Ranibizumab
UR - http://www.scopus.com/inward/record.url?scp=85087210931&partnerID=8YFLogxK
U2 - 10.1016/j.ijom.2020.05.017
DO - 10.1016/j.ijom.2020.05.017
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C2 - 32616306
AN - SCOPUS:85087210931
SN - 0901-5027
VL - 49
SP - 1589
EP - 1591
JO - International Journal of Oral and Maxillofacial Surgery
JF - International Journal of Oral and Maxillofacial Surgery
IS - 12
ER -