Medical treatment of tuberous sclerosis-related epilepsy

Shimrit Uliel-Sibony*, Veronika Chernuha, Hadas Meirson, Aviva Fattal-Valevski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Epilepsy is one of the most frequent CNS manifestations of tuberous sclerosis, and for most patients, it is the major debilitating factor. In up to 70% of the cases, the epilepsy is refractory and usually associated with significant behavioral as well as developmental consequences. Therefore, controlling seizures is one of the biggest medical and surgical challenges. Understanding the cellular mechanism involved in the disease empowered targeted research aimed toward early intervention in the epileptogenicity process. In this review, we present an update on the pharmacological treatments in tuberous sclerosis-related epilepsy.

Original languageEnglish
Pages (from-to)2511-2517
Number of pages7
JournalChild's Nervous System
Issue number10
StatePublished - 1 Oct 2020
Externally publishedYes


  • Drug therapy
  • Epilepsy
  • Tuberous sclerosis


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