TY - JOUR
T1 - Mechanisms shaping cell membranes
AU - Kozlov, Michael M.
AU - Campelo, Felix
AU - Liska, Nicole
AU - Chernomordik, Leonid V.
AU - Marrink, Siewert J.
AU - McMahon, Harvey T.
N1 - Funding Information:
We thank Tom Rapoport for critical reading of the manuscript, Eva Schmid for the His-proteins (as in [ 44 ]) used for generation of the data presented in Figure 1 , and Wai-Ching Hon for assembling the panels of Figure 3 . MMK is supported by the Israel Science Foundation (ISF) (grant no. 758/11 ), and holds the Joseph Klafter Chair in Biophysics. The research of LVC is supported by the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health.
PY - 2014/8
Y1 - 2014/8
N2 - Membranes of intracellular organelles are characterized by large curvatures with radii of the order of 10-30. nm. While, generally, membrane curvature can be a consequence of any asymmetry between the membrane monolayers, generation of large curvatures requires the action of mechanisms based on specialized proteins. Here we discuss the three most relevant classes of such mechanisms with emphasis on the physical requirements for proteins to be effective in generation of membrane curvature. We provide new quantitative estimates of membrane bending by shallow hydrophobic insertions and compare the efficiency of the insertion mechanism with those of the protein scaffolding and crowding mechanisms.
AB - Membranes of intracellular organelles are characterized by large curvatures with radii of the order of 10-30. nm. While, generally, membrane curvature can be a consequence of any asymmetry between the membrane monolayers, generation of large curvatures requires the action of mechanisms based on specialized proteins. Here we discuss the three most relevant classes of such mechanisms with emphasis on the physical requirements for proteins to be effective in generation of membrane curvature. We provide new quantitative estimates of membrane bending by shallow hydrophobic insertions and compare the efficiency of the insertion mechanism with those of the protein scaffolding and crowding mechanisms.
UR - http://www.scopus.com/inward/record.url?scp=84898926425&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2014.03.006
DO - 10.1016/j.ceb.2014.03.006
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C2 - 24747171
AN - SCOPUS:84898926425
SN - 0955-0674
VL - 29
SP - 53
EP - 60
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 1
ER -