Mechanisms of RIPK3-induced inflammation

Inbar Shlomovitz, Sefi Zargrian, Motti Gerlic

Research output: Contribution to journalReview articlepeer-review

Abstract

Receptor-interacting protein kinase 3 (RIP3/RIPK3) is a multifunctional regulator of cell death and inflammation. It controls signalling downstream of the tumor necrosis factor (TNF) receptor family, DNA-dependent activator of IFN-regulatory factors (DAI) and toll-like receptors (TLRs). Today, it is also widely recognized as a component of caspase-independent cell death known as necroptosis, and cytokine production via activation of the inflammasome. Its role in inflammasome activation, in particular, make the interpretation of its role in vivo more complex. In this review, we focus on divergent roles for RIPK3 in cell death and inflammation.

Original languageEnglish
Pages (from-to)166-172
Number of pages7
JournalImmunology and Cell Biology
Volume95
Issue number2
DOIs
StatePublished - 1 Feb 2017

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