Mechanisms of adult human β-cell in vitro dedifferentiation and redifferentiation

S. Efrat*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Recent studies in animal models and human pathological specimens suggest the involvement of β-cell dedifferentiation in β-cell dysfunction associated with type 2 diabetes. Dedifferentiated β-cells may be exploited for endogenous renewal of the β-cell mass. However, studying human β-cell dedifferentiation in diabetes presents major difficulties. We have analysed mechanisms involved in human β-cell dedifferentiation in vitro, under conditions that allow cell proliferation. Although there are important differences between the two cellular environments, β-cell dedifferentiation in the two conditions is likely to share a number of common pathways. Insights from the in vitro studies may lead to development of approaches for redifferentiation of endogenous dedifferentiated β-cells.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalDiabetes, Obesity and Metabolism
Volume18
DOIs
StatePublished - 1 Sep 2016

Funding

FundersFunder number
Israel Ministry of Industry, Trade, and Labor Kamin Program
Juvenile Diabetes Research Foundation International
Israel Science Foundation

    Keywords

    • cell-lineage tracing
    • signalling pathways
    • type 2 diabetes
    • β-cell proliferation

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