Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome

Anabel L. Aron, A. E. Gharavi, Yehuda Shoenfeld

Research output: Contribution to journalArticlepeer-review

Abstract

Antiphospholipid antibody syndrome (APS) is characterized by autoantibodics against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not dear. We review the possible mechanisms of action of antiphospholipid (aPL) antibodies. Apparently, aPL antibodies act by interfering with coagulation, involving both endothelial cclls, platelets, and humoral components, and affect pregnancy outcome by interfering with embryo implantation and fetal developement.

Original languageEnglish
Pages (from-to)8-12
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume106
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

Keywords

  • Anticardiolipin antibody
  • Antiphospholipid antibody syndrome
  • Antithrombin iii
  • Fetal loss
  • Lupus anticoagulant
  • Platelets
  • Protein c
  • Sle
  • Thrombosis
  • β<inf>2</inf>-glycoprotein i

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