Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome

Anabel L. Aron; A. E. Gharavi; Yehuda Shoenfeld

doi:10.1159/000236883

Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome

Anabel L. Aron, A. E. Gharavi^*, Yehuda Shoenfeld

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Antiphospholipid antibody syndrome (APS) is characterized by autoantibodics against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not dear. We review the possible mechanisms of action of antiphospholipid (aPL) antibodies. Apparently, aPL antibodies act by interfering with coagulation, involving both endothelial cclls, platelets, and humoral components, and affect pregnancy outcome by interfering with embryo implantation and fetal developement.

Original language	English
Pages (from-to)	8-12
Number of pages	5
Journal	International Archives of Allergy and Immunology
Volume	106
Issue number	1
DOIs	https://doi.org/10.1159/000236883
State	Published - 1995
Externally published	Yes

Keywords

Anticardiolipin antibody
Antiphospholipid antibody syndrome
Antithrombin iii
Fetal loss
Lupus anticoagulant
Platelets
Protein c
Sle
Thrombosis
β<inf>2</inf>-glycoprotein i

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title = "Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome",

abstract = "Antiphospholipid antibody syndrome (APS) is characterized by autoantibodics against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not dear. We review the possible mechanisms of action of antiphospholipid (aPL) antibodies. Apparently, aPL antibodies act by interfering with coagulation, involving both endothelial cclls, platelets, and humoral components, and affect pregnancy outcome by interfering with embryo implantation and fetal developement.",

keywords = "Anticardiolipin antibody, Antiphospholipid antibody syndrome, Antithrombin iii, Fetal loss, Lupus anticoagulant, Platelets, Protein c, Sle, Thrombosis, β<inf>2</inf>-glycoprotein i",

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AB - Antiphospholipid antibody syndrome (APS) is characterized by autoantibodics against negatively charged phospholipids in the serum, and clinically by multiple thromboses, thrombocytopenia, and recurrent fetal loss. The mechanism(s) by which the antibodies cause the clinical picture are not dear. We review the possible mechanisms of action of antiphospholipid (aPL) antibodies. Apparently, aPL antibodies act by interfering with coagulation, involving both endothelial cclls, platelets, and humoral components, and affect pregnancy outcome by interfering with embryo implantation and fetal developement.

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KW - Lupus anticoagulant

KW - Platelets

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KW - Sle

KW - Thrombosis

KW - β<inf>2</inf>-glycoprotein i

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Mechanisms of action of antiphospholipid antibodies in the antiphospholipid syndrome

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