Mechanism of heparin rebound: In vitro study

Ina Fabian; Moshe Aronson

doi:10.1016/0049-3848(80)90349-7

Mechanism of heparin rebound: In vitro study

Ina Fabian^*, Moshe Aronson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The mechanism of heparin rebound is still unclear and the present study reports on its successful reproduction under in vitro conditions. By measuring clotting time, by the use of electrophoretic techniques and with the employ of protease inhibitors it was found that protamine is proteolytically degraded on incubation in plasma. The obtained results suggest that heparin rebound entails the degradation of protamine and the release of the previously bound heparin into the circulation.

Original language	English
Pages (from-to)	535-542
Number of pages	8
Journal	Thrombosis Research
Volume	18
Issue number	3-4
DOIs	https://doi.org/10.1016/0049-3848(80)90349-7
State	Published - 1980

Keywords

Heparin
Protamine
Rebound

Access to Document

10.1016/0049-3848(80)90349-7

Cite this

@article{228b306e6d8647a28783fe5ab3402927,

title = "Mechanism of heparin rebound: In vitro study",

abstract = "The mechanism of heparin rebound is still unclear and the present study reports on its successful reproduction under in vitro conditions. By measuring clotting time, by the use of electrophoretic techniques and with the employ of protease inhibitors it was found that protamine is proteolytically degraded on incubation in plasma. The obtained results suggest that heparin rebound entails the degradation of protamine and the release of the previously bound heparin into the circulation.",

keywords = "Heparin, Protamine, Rebound",

author = "Ina Fabian and Moshe Aronson",

year = "1980",

doi = "10.1016/0049-3848(80)90349-7",

language = "אנגלית",

volume = "18",

pages = "535--542",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier Ltd.",

number = "3-4",

}

TY - JOUR

T1 - Mechanism of heparin rebound

T2 - In vitro study

AU - Fabian, Ina

AU - Aronson, Moshe

PY - 1980

Y1 - 1980

N2 - The mechanism of heparin rebound is still unclear and the present study reports on its successful reproduction under in vitro conditions. By measuring clotting time, by the use of electrophoretic techniques and with the employ of protease inhibitors it was found that protamine is proteolytically degraded on incubation in plasma. The obtained results suggest that heparin rebound entails the degradation of protamine and the release of the previously bound heparin into the circulation.

AB - The mechanism of heparin rebound is still unclear and the present study reports on its successful reproduction under in vitro conditions. By measuring clotting time, by the use of electrophoretic techniques and with the employ of protease inhibitors it was found that protamine is proteolytically degraded on incubation in plasma. The obtained results suggest that heparin rebound entails the degradation of protamine and the release of the previously bound heparin into the circulation.

KW - Heparin

KW - Protamine

KW - Rebound

UR - http://www.scopus.com/inward/record.url?scp=0018885141&partnerID=8YFLogxK

U2 - 10.1016/0049-3848(80)90349-7

DO - 10.1016/0049-3848(80)90349-7

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0018885141

SN - 0049-3848

VL - 18

SP - 535

EP - 542

JO - Thrombosis Research

JF - Thrombosis Research

IS - 3-4

ER -

Mechanism of heparin rebound: In vitro study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this