Mechanism of heparin rebound: In vitro study

Ina Fabian*, Moshe Aronson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The mechanism of heparin rebound is still unclear and the present study reports on its successful reproduction under in vitro conditions. By measuring clotting time, by the use of electrophoretic techniques and with the employ of protease inhibitors it was found that protamine is proteolytically degraded on incubation in plasma. The obtained results suggest that heparin rebound entails the degradation of protamine and the release of the previously bound heparin into the circulation.

Original languageEnglish
Pages (from-to)535-542
Number of pages8
JournalThrombosis Research
Issue number3-4
StatePublished - 1980


  • Heparin
  • Protamine
  • Rebound


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