Mechanism of gnrh receptor signaling: From the membrane to the nucleus

S. Shacham; M. N. Cheifetz; H. Lewy; I. E. Ashkenazi; O. M. Becker; R. Seger; Z. Naor

Mechanism of gnrh receptor signaling: From the membrane to the nucleus

S. Shacham^*, M. N. Cheifetz, H. Lewy, I. E. Ashkenazi, O. M. Becker, R. Seger, Z. Naor

^*Corresponding author for this work

Biochemistry Molecular Biology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G₁₁ protein and to activation of phospholipase Cβ. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A₂ and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.

Original language	English
Pages (from-to)	79-88
Number of pages	10
Journal	Annales d'Endocrinologie
Volume	60
Issue number	2
State	Published - Jul 1999

Keywords

Arachidonic acid
Ca
Dephosphorylation
Desensitization
G-proteins
GnRH
GnRH receptor
Gonadotropin release
JUN kinase
MAP kinase
Phosphorylation
Protein kinase C

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Mechanism of gnrh receptor signaling: From the membrane to the nucleus",

abstract = "The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase Cβ. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A2 and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.",

keywords = "Arachidonic acid, Ca, Dephosphorylation, Desensitization, G-proteins, GnRH, GnRH receptor, Gonadotropin release, JUN kinase, MAP kinase, Phosphorylation, Protein kinase C",

author = "S. Shacham and Cheifetz, \{M. N.\} and H. Lewy and Ashkenazi, \{I. E.\} and Becker, \{O. M.\} and R. Seger and Z. Naor",

year = "1999",

month = jul,

language = "אנגלית",

volume = "60",

pages = "79--88",

journal = "Annales d'Endocrinologie",

issn = "0003-4266",

publisher = "Elsevier Masson s.r.l.",

number = "2",

}

TY - JOUR

T1 - Mechanism of gnrh receptor signaling

T2 - From the membrane to the nucleus

AU - Shacham, S.

AU - Cheifetz, M. N.

AU - Lewy, H.

AU - Ashkenazi, I. E.

AU - Becker, O. M.

AU - Seger, R.

AU - Naor, Z.

PY - 1999/7

Y1 - 1999/7

N2 - The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase Cβ. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A2 and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.

AB - The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase Cβ. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A2 and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.

KW - Arachidonic acid

KW - Ca

KW - Dephosphorylation

KW - Desensitization

KW - G-proteins

KW - GnRH

KW - GnRH receptor

KW - Gonadotropin release

KW - JUN kinase

KW - MAP kinase

KW - Phosphorylation

KW - Protein kinase C

UR - https://www.scopus.com/pages/publications/0032774921

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:0032774921

SN - 0003-4266

VL - 60

SP - 79

EP - 88

JO - Annales d'Endocrinologie

JF - Annales d'Endocrinologie

IS - 2

ER -

Mechanism of gnrh receptor signaling: From the membrane to the nucleus

Abstract

Keywords

UN SDGs

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