Mechanism of gnrh receptor signaling: From the membrane to the nucleus

S. Shacham, M. N. Cheifetz, H. Lewy, I. E. Ashkenazi, O. M. Becker, R. Seger, Z. Naor

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this review is to update the information concerning the intracellular effect of GnRH. Binding of GnRH to a G-protein coupled receptor leads to stimulation of Gq and/or G11 protein and to activation of phospholipase Cβ. Inositol 1-4-5-triphosphate and early diacylylycerol are the second messengers required for conventional protein kinase C activation. Activation of phospholipase A2 and phospholipase D are also involved, as demonstrated by the liberation of Arachidonic Acid and Phosphatidic Acid. Pituitary cells also express atypical protein kinase C isoforms which mode of activation is not known. Hypothesis concerning transcriptional regulation are presented.

Original languageEnglish
Pages (from-to)79-88
Number of pages10
JournalAnnales d'Endocrinologie
Volume60
Issue number2
StatePublished - Jul 1999

Keywords

  • Arachidonic acid
  • Ca
  • Dephosphorylation
  • Desensitization
  • G-proteins
  • GnRH
  • GnRH receptor
  • Gonadotropin release
  • JUN kinase
  • MAP kinase
  • Phosphorylation
  • Protein kinase C

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