TY - JOUR
T1 - Mechanical strength and intracellular uptake of CaCO3-templated LbL capsules composed of biodegradable polyelectrolytes
T2 - The influence of the number of layers
AU - Palankar, Raghavendra
AU - Pinchasik, Bat El
AU - Schmidt, Stephan
AU - De Geest, Bruno G.
AU - Fery, Andreas
AU - Möhwald, Helmuth
AU - Skirtach, André G.
AU - Delcea, Mihaela
PY - 2013/2/28
Y1 - 2013/2/28
N2 - Developing carriers comprised of biomaterials and capable of withstanding significant mechanical pressures, structural deformations and at the same time delivering biomolecules is of high interest for drug delivery. Using colloidal probe AFM combined with quantitative fluorescence microscopy, we investigated mechanical properties and release from CaCO3-templated polymeric capsules made of biodegradable polymers. The mechanical and release properties of these capsules were studied in comparison with those of CaCO 3-templated capsules composed of synthetic polymers. Furthermore, we assessed the influence of the number of polyelectrolyte LbL layers on the mechanical properties and release from biodegradable capsules. Mechanical deformation of capsules was studied upon intracellular uptake of these capsules. Based on these results, we discuss implications for the design of microcapsules.
AB - Developing carriers comprised of biomaterials and capable of withstanding significant mechanical pressures, structural deformations and at the same time delivering biomolecules is of high interest for drug delivery. Using colloidal probe AFM combined with quantitative fluorescence microscopy, we investigated mechanical properties and release from CaCO3-templated polymeric capsules made of biodegradable polymers. The mechanical and release properties of these capsules were studied in comparison with those of CaCO 3-templated capsules composed of synthetic polymers. Furthermore, we assessed the influence of the number of polyelectrolyte LbL layers on the mechanical properties and release from biodegradable capsules. Mechanical deformation of capsules was studied upon intracellular uptake of these capsules. Based on these results, we discuss implications for the design of microcapsules.
UR - http://www.scopus.com/inward/record.url?scp=84876548175&partnerID=8YFLogxK
U2 - 10.1039/c2tb00319h
DO - 10.1039/c2tb00319h
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AN - SCOPUS:84876548175
SN - 2050-7518
VL - 1
SP - 1175
EP - 1181
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 8
ER -