Mechanical properties and histology of charge modified bioprosthetic tissue resistant to calcification

Gershon Golomb, Israel Lewinstein, Vittoria Ezra, Frederick J. Schoen

Research output: Contribution to journalArticlepeer-review

Abstract

Modification of bioprosthetic heart valves tissue by covalently binding protamine sulphate, results in stable covalent links of protamine to the tissue, conferring resistance to calcification. We report here the morphological evaluation and mechanical properties (elastic modulus and ultimate tensile strength) of protamine-bound bioprosthetic tissues that have high anticalcification potential. Protamine-bound bioprosthetic tissue had significantly higher tissue modulus and ultimate tensile strength values than control tissue groups. However, the mechanical properties and tissue architecture were inferior to those of bioprosthetic tissue.

Original languageEnglish
Pages (from-to)353-356
Number of pages4
JournalBiomaterials
Volume13
Issue number6
DOIs
StatePublished - 1992
Externally publishedYes

Keywords

  • Calcification
  • heart valve prostheses
  • mechanical properties
  • surface modification

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