Measles virus P gene codes for two proteins

W. J. Bellini, G. Englund, S. Rozenblatt, H. Arnheiter, C. D. Richardson

Research output: Contribution to journalArticlepeer-review

Abstract

The entirety of the phosphoprotein gene of measles virus has been sequenced. The gene is composed of 1,657 nucleotides and specifies a 507-amino-acid protein (P). A second overlapping reading frame was predicted from the sequence and specifies a 186-amino-acid protein (C). Through the use of antisynthetic peptide antibodies, we show that both proteins are expressed in virally infected cells. Both proteins are expressed from a functionally bicistronic mRNA through independent initiation of ribosomes at the respective AUG codons. Using immunofluorescent microscopy, we localized the C protein in the nucleus and in cytoplasmic inclusions within the infected cells.

Original languageEnglish
Pages (from-to)908-919
Number of pages12
JournalJournal of Virology
Volume53
Issue number3
DOIs
StatePublished - 1985
Externally publishedYes

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