Measles-vaccinated Israeli boy with subacute sclerosing panencephalitis

Ronly Har-Even, Sergio Aichenbaum, Jose M. Rabey, Amir Livne, Tzvy Bistritzer

Research output: Contribution to journalArticlepeer-review

Abstract

Subacute sclerosing panencephalitis is a rare neurologic disorder of childhood and adolescence. We describe a 16-year-old boy who manifested the disease despite proper vaccinations. He was hospitalized because of bedwetting, involuntary limb movements, abnormal speech, and balance disturbances. Immunoglobulin G antibodies against measles were strongly positive, with a high relative cerebrospinal fluid/serum ratio. Polymerase chain reaction for measles produced negative results. Electroencephalography registered slow activity with high voltage discharges every few seconds, and with triphasic complex morphology. Magnetic resonance imaging revealed diffuse white matter changes, mostly around the posterior regions and lateral ventricles. Treatment with valproic acid, levetiracetam, carbamazepine, and intravenous immunoglobulin G was ineffective. Inosiplex and interferon-β-1a were also administrated. The patient became comatose, with generalized myoclonic jerks, and died 1 year later. An autopsy was not performed. This patient illustrates that subacute sclerosing panencephalitis should be suspected among young vaccinated subjects.

Original languageEnglish
Pages (from-to)467-470
Number of pages4
JournalPediatric Neurology
Volume44
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

Fingerprint

Dive into the research topics of 'Measles-vaccinated Israeli boy with subacute sclerosing panencephalitis'. Together they form a unique fingerprint.

Cite this