TY - JOUR
T1 - Maximum Likelihood Estimator and Likelihood Ratio Test in Complex Models
T2 - An Application to B Lymphocyte Development
AU - Gorfine, Malka
AU - Freedman, Laurence
AU - Shahaf, Gitit
AU - Mehr, Ramit
N1 - Funding Information:
We are grateful to Dr M Cancro for the collaboration of B cell development and the use of the data, and to Dr A Neumann for useful discussions. Supported in part by Israel Science Foundation—The Dorot Science Fellowship Foundation grant number 759/01-1, The Yigal Alon Fellowship, and a Bar-Ilan University internal grant (to RM).
PY - 2003/11
Y1 - 2003/11
N2 - In this paper we introduce a simple framework which provides a basis for estimating parameters and testing statistical hypotheses in complex models. The only assumption that is made in the model describing the process under study, is that the deviations of the observations from the model have a multivariate normal distribution. The application of the statistical techniques presented in this paper may have considerable utility in the analysis of a wide variety of complex biological and epidemiological models. To our knowledge, the model and methods described here have not previously been published in the area of theoretical immunology.
AB - In this paper we introduce a simple framework which provides a basis for estimating parameters and testing statistical hypotheses in complex models. The only assumption that is made in the model describing the process under study, is that the deviations of the observations from the model have a multivariate normal distribution. The application of the statistical techniques presented in this paper may have considerable utility in the analysis of a wide variety of complex biological and epidemiological models. To our knowledge, the model and methods described here have not previously been published in the area of theoretical immunology.
UR - http://www.scopus.com/inward/record.url?scp=0344962432&partnerID=8YFLogxK
U2 - 10.1016/S0092-8240(03)00062-4
DO - 10.1016/S0092-8240(03)00062-4
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C2 - 14607292
AN - SCOPUS:0344962432
SN - 0092-8240
VL - 65
SP - 1131
EP - 1139
JO - Bulletin of Mathematical Biology
JF - Bulletin of Mathematical Biology
IS - 6
ER -