@article{55e4a1310d8f4365a855fac0c99c03eb,
title = "Maternal snoring during pregnancy is associated with enhanced fetal erythropoiesis - a preliminary study",
abstract = "Objective and background: Snoring is common among pregnant women and early reports suggest that it may bear a risk to the fetus. Increased fetal erythropoiesis manifested by elevated circulating nucleated red blood cells (nRBCs) has been found in complicated pregnancies involving fetal hypoxia. Both erythropoietin (EPO) and interleukin-6 (IL-6) mediate elevation of circulating nRBCs. The intermittent hypoxia and systemic inflammation elicited by sleep-disordered breathing (SDB) could affect fetal erythropoiesis during pregnancy. We hypothesized that maternal snoring will result in increased levels of fetal circulating nRBCs via increased concentrations of EPO, IL-6, or both. Methods: Women of singleton uncomplicated full-term pregnancies were recruited during labor and completed a designated questionnaire. Umbilical cord blood was collected immediately after birth and analyzed for nRBCs, plasma EPO and plasma IL-6 concentrations. Newborn data were retrieved from medical records. Results: One hundred and twenty-two women were recruited. Thirty-nine percent of women reported habitual snoring during pregnancy. Cord blood levels of circulating nRBCs, EPO and IL-6 were significantly elevated in habitual snorers compared with non-snorers (p=0.03, 0.005 and 0.01; respectively). No differences in maternal characteristics or newborn crude outcomes were found. Conclusions: Maternal snoring during pregnancy is associated with enhanced fetal erythropoiesis manifested by increased cord blood levels of nRBCs, EPO and IL-6. This provides preliminary evidence that maternal snoring is associated with subtle alterations in markers of fetal well being.",
keywords = "Erythropoietin, Fetus, IL-6, Nucleated RBCs, Pregnancy, Sleep disordered breathing, Snoring",
author = "Riva Tauman and Ariel Many and Varda Deutsch and Shlomit Arvas and Jessica Ascher-Landsberg and Michal Greenfeld and Yakov Sivan",
note = "Funding Information: This research was supported by The Legacy Heritage Clinical Research Initiative of the Israel Science Foundation (Grant No. 1700/08). ",
year = "2011",
month = may,
doi = "10.1016/j.sleep.2010.09.005",
language = "אנגלית",
volume = "12",
pages = "518--522",
journal = "Sleep Medicine",
issn = "1389-9457",
publisher = "Elsevier B.V.",
number = "5",
}