Maternal serum human chorionic gonadotrophin levels in systemic lupus erythematosus and antiphospholipid syndrome

Ron Maymon, Howard Cuckle, Indera K. Sehmi, Arie Herman, Dan Sherman

Research output: Contribution to journalArticlepeer-review

Abstract

Maternal serum human chorionic gonadotrophin (hCG) levels were measured during the second and the third trimesters of pregnancy in patients with either systemic lupus erythematosus (SLE) or primary antiphospholipid syndrome (APS). All results were expressed in multiples of the gestation-specific normal medians (MoM). The median MoM level in 17 samples from SLE patients was 1.48 compared with 0.79 MoM in 99 controls of similar gestation (p <0.002, Wilcoxon Rank sum test). In contrast the median MoM level in 19 samples from primary APS patients was only 1.14. These preliminary findings should be further studied to evaluate the implications for Down syndrome screening, detection of SLE cases during pregnancy and the prediction of adverse outcome in SLE gestations.

Original languageEnglish
Pages (from-to)143-145
Number of pages3
JournalPrenatal Diagnosis
Volume21
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • Antiphospholipid syndrome (APS)
  • Human chorionic gonadotrophin
  • Pregnancy
  • Systemic lupus erythematosus (SLE)

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